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• W2045235622 abstract "Abstract (1) Maximum-likelihood methods are proposed for fitting survival curves with theoretical models. The methods give estimates of the parameters and goodness-of-fit tests. (2) The underlying theory is reviewed. (3) Application of these methods to the chloroplastic survival of Euglena gracilis led to the following results: Different models, based on target theory, give an adequate fit to the observations when each experiment is considered separately. However, there is a large variation between the estimate of the number of targets obtained from different experiments. Lack of a satisfactory explanation for this variation thus throws doubt on the validity of these simplest models. With more complex models one can postulate a constant number of target sites. These models consider the target sites as the sites of secondary effects for which variation between experiments is more easily explained. However, these models contain additional parameters which cannot be estimated from the available data, thus depriving the models of predictive value. If it were possible to obtain further experimental data from which these additional parameters could be estimated, then the predictive value of the models would be restored." @default.
• W2045235622 created "2016-06-24" @default.
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• W2045235622 date "1978-12-01" @default.
• W2045235622 modified "2023-10-01" @default.
• W2045235622 title "Fitting survival curves with theoretical models; goodness-of-fit tests and parameter estimation. application to the clonal survival of Chlorella and the chloroplastic survival of Euglena gracilis after irradiation" @default.
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• W2045235622 doi "https://doi.org/10.1016/0025-5564(78)90101-3" @default.
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