FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045235636> ?p ?o ?g. }

• W2045235636 endingPage "216" @default.
• W2045235636 startingPage "203" @default.
• W2045235636 abstract "Dopamine content in the amphibian olfactory bulb is supplied by interneurons scattered among mitral cells in the external plexiform/mitral cell layer. In mammals, dopamine has been found to be involved in various aspects of bulbar information processing by influencing mitral cell odour responsiveness. Dopamine action in the bulb depends directly on the localization of its receptor targets, found to be mainly of the D2 type in mammals. The present study assessed, in the frog, both the anatomical localization of D2-like, radioligand-labelled receptors of dopamine and the in vivo action of dopamine on unitary mitral cell activity in response to odours delivered over a wide range of concentrations. The [125I]iodosulpride-labelled D2 binding sites were visualized on frozen sagittal sections of frog brains by film radioautography. The sites were found to be restricted to the external plexiform/mitral cell layer; other layers of the olfactory bulb were devoid of specific labelling. Electrophysiological recordings of mitral unit activity revealed that dopamine or its agonist apomorphine induced a drastic reduction of spontaneous firing rate of mitral cells in most cases without altering odour intensity coding properties of these cells. Moreover, pre-treatment with the D2 antagonist eticlopride blocked the dopamine-induced reduction of mitral cell spontaneous activity. In the frog olfactory bulb, both anatomical localization of D2-like receptors and functional data on dopamine involvement in information processing differ from those reported in mammals. This suggests a phylogenetic evolution of dopamine action in the olfactory bulb. In the frog, anatomical data perfectly corroborate electrophysiological results, together strongly suggesting a direct action of dopamine on mitral cells. In a physiologically operating system, such an action would result in a global improvement of signal-to-noise ratio." @default.
• W2045235636 created "2016-06-24" @default.
• W2045235636 creator A5011532872 @default.
• W2045235636 creator A5020614130 @default.
• W2045235636 creator A5031153848 @default.
• W2045235636 creator A5065279691 @default.
• W2045235636 creator A5089295268 @default.
• W2045235636 date "1997-04-01" @default.
• W2045235636 modified "2023-09-27" @default.
• W2045235636 title "Dopaminergic modulation of mitral cell activity in the frog olfactory bulb: a combined radioligand binding–electrophysiological study" @default.
• W2045235636 cites W125141985 @default.
• W2045235636 cites W1508445445 @default.
• W2045235636 cites W1579126107 @default.
• W2045235636 cites W1601345792 @default.
• W2045235636 cites W1884206649 @default.
• W2045235636 cites W1964796797 @default.
• W2045235636 cites W1965236514 @default.
• W2045235636 cites W1966092598 @default.
• W2045235636 cites W1967633802 @default.
• W2045235636 cites W1968060871 @default.
• W2045235636 cites W1970605735 @default.
• W2045235636 cites W1972434563 @default.
• W2045235636 cites W1976045951 @default.
• W2045235636 cites W1976640346 @default.
• W2045235636 cites W1985582613 @default.
• W2045235636 cites W1989624193 @default.
• W2045235636 cites W1990775210 @default.
• W2045235636 cites W1992113599 @default.
• W2045235636 cites W1995438606 @default.
• W2045235636 cites W1999663904 @default.
• W2045235636 cites W2001233053 @default.
• W2045235636 cites W2001668370 @default.
• W2045235636 cites W2017007418 @default.
• W2045235636 cites W2022151784 @default.
• W2045235636 cites W2026339353 @default.
• W2045235636 cites W2027814303 @default.
• W2045235636 cites W2030749071 @default.
• W2045235636 cites W2031472223 @default.
• W2045235636 cites W2039152833 @default.
• W2045235636 cites W2043393596 @default.
• W2045235636 cites W2048937194 @default.
• W2045235636 cites W2049291384 @default.
• W2045235636 cites W2052805851 @default.
• W2045235636 cites W2056476441 @default.
• W2045235636 cites W2057440029 @default.
• W2045235636 cites W2057996784 @default.
• W2045235636 cites W2059312247 @default.
• W2045235636 cites W2059341102 @default.
• W2045235636 cites W2067028469 @default.
• W2045235636 cites W2069266927 @default.
• W2045235636 cites W2070965540 @default.
• W2045235636 cites W2071045607 @default.
• W2045235636 cites W2071578692 @default.
• W2045235636 cites W2079128738 @default.
• W2045235636 cites W2079131087 @default.
• W2045235636 cites W2081323923 @default.
• W2045235636 cites W2087153104 @default.
• W2045235636 cites W2090408575 @default.
• W2045235636 cites W2092013136 @default.
• W2045235636 cites W2092750152 @default.
• W2045235636 cites W2122088060 @default.
• W2045235636 cites W2142092624 @default.
• W2045235636 cites W2147221228 @default.
• W2045235636 cites W2151974616 @default.
• W2045235636 cites W2160603177 @default.
• W2045235636 cites W2169760312 @default.
• W2045235636 cites W2418924108 @default.
• W2045235636 cites W4239436839 @default.
• W2045235636 cites W4245274079 @default.
• W2045235636 doi "https://doi.org/10.1016/s0306-4522(96)00646-x" @default.
• W2045235636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9178876" @default.
• W2045235636 hasPublicationYear "1997" @default.
• W2045235636 type Work @default.
• W2045235636 sameAs 2045235636 @default.
• W2045235636 citedByCount "51" @default.
• W2045235636 countsByYear W20452356362012 @default.
• W2045235636 countsByYear W20452356362013 @default.
• W2045235636 countsByYear W20452356362014 @default.
• W2045235636 countsByYear W20452356362015 @default.
• W2045235636 countsByYear W20452356362016 @default.
• W2045235636 countsByYear W20452356362017 @default.
• W2045235636 countsByYear W20452356362019 @default.
• W2045235636 countsByYear W20452356362020 @default.
• W2045235636 countsByYear W20452356362021 @default.
• W2045235636 crossrefType "journal-article" @default.
• W2045235636 hasAuthorship W2045235636A5011532872 @default.
• W2045235636 hasAuthorship W2045235636A5020614130 @default.
• W2045235636 hasAuthorship W2045235636A5031153848 @default.
• W2045235636 hasAuthorship W2045235636A5065279691 @default.
• W2045235636 hasAuthorship W2045235636A5089295268 @default.
• W2045235636 hasConcept C120069818 @default.
• W2045235636 hasConcept C126322002 @default.
• W2045235636 hasConcept C134018914 @default.
• W2045235636 hasConcept C137183658 @default.
• W2045235636 hasConcept C169760540 @default.
• W2045235636 hasConcept C185263204 @default.
• W2045235636 hasConcept C2777525119 @default.
• W2045235636 hasConcept C2778125517 @default.

• next