Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045239093> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2045239093 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILBreast cancer is the second-leading cause of cancer death among women in the United States and the progression from non-invasive to invasive/metastatic disease correlates with an increased risk of death. Changes in DNA methylation have been shown to be important in breast cancers. However, the mechanism by which cancer cells acquire and maintain abnormal methylation is not well understood. DNA methyltransferases (DNMTs) are responsible for monitoring and altering DNA methylation patterns in cells. Interestingly, we have identified many aberrant DNMT3B transcripts in cancer cells compared to normal cells. Therefore, we hypothesize that aberrant DNMT3B isoforms alter gene and protein expression to promote tumor progression in breast cancer cells. Our studies indicate that the breast cancer cell lines MCF-7 and MDA-MB-231 express many aberrant DNMT3B isoforms including DNMT3B7 and ΔDNMT3B6. Interestingly, the invasive MDA-MB-231 cells express increased levels of DNMT3B7 and ΔDNMT3B6 compared to the poorly invasive MCF-7 cells. To further our studies, poorly invasive MCF-7 cells were stably transfected with a DNMT3B7 expression construct to determine the role of this aberrant transcript in tumor progression. Preliminary data indicate that the increased expression of DNMT3B7 in these cells correlates with a significant increase in growth. Specifically, cells expressing more DNMT3B7 grow faster than those with lower levels of the aberrant protein. Furthermore, E-cadherin expression is inversely correlated with DNMT3B7 expression indicating that the expression of this aberrant protein may lead to a more aggressive phenotype. Finally, soft agar assays have been performed to determine the functional significance of these findings. The novel results presented in this study suggest the need for additional studies to determine the role of aberrant DNMT3B transcripts in cancer. Ultimately, this work may lead to a better understanding of breast cancer progression and the development of novel therapeutics.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1053. doi:1538-7445.AM2012-1053" @default.
- W2045239093 created "2016-06-24" @default.
- W2045239093 creator A5029649755 @default.
- W2045239093 creator A5036669755 @default.
- W2045239093 creator A5043998517 @default.
- W2045239093 creator A5058664440 @default.
- W2045239093 creator A5065240782 @default.
- W2045239093 creator A5075661708 @default.
- W2045239093 creator A5082504350 @default.
- W2045239093 date "2012-04-15" @default.
- W2045239093 modified "2023-09-27" @default.
- W2045239093 title "Abstract 1053: DNMT3B7 alters E-cadherin expression and cell proliferation in breast cancer cells" @default.
- W2045239093 doi "https://doi.org/10.1158/1538-7445.am2012-1053" @default.
- W2045239093 hasPublicationYear "2012" @default.
- W2045239093 type Work @default.
- W2045239093 sameAs 2045239093 @default.
- W2045239093 citedByCount "0" @default.
- W2045239093 crossrefType "proceedings-article" @default.
- W2045239093 hasAuthorship W2045239093A5029649755 @default.
- W2045239093 hasAuthorship W2045239093A5036669755 @default.
- W2045239093 hasAuthorship W2045239093A5043998517 @default.
- W2045239093 hasAuthorship W2045239093A5058664440 @default.
- W2045239093 hasAuthorship W2045239093A5065240782 @default.
- W2045239093 hasAuthorship W2045239093A5075661708 @default.
- W2045239093 hasAuthorship W2045239093A5082504350 @default.
- W2045239093 hasConcept C104317684 @default.
- W2045239093 hasConcept C121608353 @default.
- W2045239093 hasConcept C150194340 @default.
- W2045239093 hasConcept C190727270 @default.
- W2045239093 hasConcept C2777142704 @default.
- W2045239093 hasConcept C2779256057 @default.
- W2045239093 hasConcept C33288867 @default.
- W2045239093 hasConcept C502942594 @default.
- W2045239093 hasConcept C530470458 @default.
- W2045239093 hasConcept C54009773 @default.
- W2045239093 hasConcept C54355233 @default.
- W2045239093 hasConcept C81885089 @default.
- W2045239093 hasConcept C86803240 @default.
- W2045239093 hasConcept C91965660 @default.
- W2045239093 hasConcept C96232424 @default.
- W2045239093 hasConceptScore W2045239093C104317684 @default.
- W2045239093 hasConceptScore W2045239093C121608353 @default.
- W2045239093 hasConceptScore W2045239093C150194340 @default.
- W2045239093 hasConceptScore W2045239093C190727270 @default.
- W2045239093 hasConceptScore W2045239093C2777142704 @default.
- W2045239093 hasConceptScore W2045239093C2779256057 @default.
- W2045239093 hasConceptScore W2045239093C33288867 @default.
- W2045239093 hasConceptScore W2045239093C502942594 @default.
- W2045239093 hasConceptScore W2045239093C530470458 @default.
- W2045239093 hasConceptScore W2045239093C54009773 @default.
- W2045239093 hasConceptScore W2045239093C54355233 @default.
- W2045239093 hasConceptScore W2045239093C81885089 @default.
- W2045239093 hasConceptScore W2045239093C86803240 @default.
- W2045239093 hasConceptScore W2045239093C91965660 @default.
- W2045239093 hasConceptScore W2045239093C96232424 @default.
- W2045239093 hasLocation W20452390931 @default.
- W2045239093 hasOpenAccess W2045239093 @default.
- W2045239093 hasPrimaryLocation W20452390931 @default.
- W2045239093 hasRelatedWork W1966236033 @default.
- W2045239093 hasRelatedWork W1985492248 @default.
- W2045239093 hasRelatedWork W1996500685 @default.
- W2045239093 hasRelatedWork W2006251303 @default.
- W2045239093 hasRelatedWork W2011604806 @default.
- W2045239093 hasRelatedWork W2014801436 @default.
- W2045239093 hasRelatedWork W2067852461 @default.
- W2045239093 hasRelatedWork W2087985823 @default.
- W2045239093 hasRelatedWork W2114479856 @default.
- W2045239093 hasRelatedWork W2122431346 @default.
- W2045239093 hasRelatedWork W2161697859 @default.
- W2045239093 hasRelatedWork W2163810341 @default.
- W2045239093 hasRelatedWork W2308004123 @default.
- W2045239093 hasRelatedWork W2330528678 @default.
- W2045239093 hasRelatedWork W2335631453 @default.
- W2045239093 hasRelatedWork W2563104755 @default.
- W2045239093 hasRelatedWork W2737277743 @default.
- W2045239093 hasRelatedWork W2811241335 @default.
- W2045239093 hasRelatedWork W2890094212 @default.
- W2045239093 hasRelatedWork W2968075657 @default.
- W2045239093 isParatext "false" @default.
- W2045239093 isRetracted "false" @default.
- W2045239093 magId "2045239093" @default.
- W2045239093 workType "article" @default.