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- W2045239619 abstract "Abstract Objective We sought to identify the prevalence of MRI features of disproportionately enlarged subarachnoid space hydrocephalus in possible idiopathic normal pressure hydrocephalus (DESH‐ iNPH ) and to describe the clinico‐radiological features and outcomes of a community‐based investigation (The Vienna Trans‐Danube Aging study). Methods Of the 697 inhabitants (all 75 years old), 503 completed extensive neurological examinations at baseline and were followed up every 30 months thereafter with MRI s, mini‐mental state examination ( MMSE ), and the Unified Parkinson Disease Rating Scale‐Motor Section ( UPDRSM ). The DESH ‐ iNPH participant data were compared with the data from participants with Evans index ratios >0.3 (ex vacuo hydrocephalus), cerebral small‐vessel diseases, and normal MRI s. The widening of perivascular space was also evaluated by MRI in these groups. Results Eight participants with DESH ‐ iNPH (1.6%) and 76 with ex vacuo hydrocephalus (16.1%) at baseline were identified. The mean MMSE in DESH ‐ iNPH , ex vacuo hydrocephalus, and normal MRI s was 26.4, 27.9, and 28.3, respectively, and the mean UPDRSM was 9.75, 2.96, and 1.87, respectively. After a 90‐month follow‐up, the mortality rates for DESH ‐ iNPH , ex vacuo hydrocephalus, and normal MRI s were 25.0%, 21.3%, and 10.9%, respectively. The perivascular‐space widening scores were significantly smaller in the DESH ‐ iNPH cases, particularly at the centrum semiovale, compared to cerebral small‐vessel disease and ex vacuo hydrocephalus cases. Interpretation The prevalence of DESH ‐ iNPH was 1.6% for participants aged 75 years and revealed significantly lower MMSE and higher UPDRSM scores compared to the ex vacuo hydrocephalus and controls. Moreover, it is suggested that perivascular‐space narrowing is a morphological and pathophysiological marker of DESH ‐ iNPH ." @default.
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- W2045239619 date "2014-07-28" @default.
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- W2045239619 title "Disproportionate subarachnoid space hydrocephalus—outcome and perivascular space" @default.
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- W2045239619 doi "https://doi.org/10.1002/acn3.87" @default.
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