FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045241531> ?p ?o ?g. }

• W2045241531 endingPage "278" @default.
• W2045241531 startingPage "273" @default.
• W2045241531 abstract "The role of antibody in neonatal herpes simplex virus (HSV) infection remains controversial. A battery of well-characterized monoclonal antibodies to HSV glycoprotein B (gB), and polyclonal antibodies against synthetic peptides of predicted epitopes of HSV glycoprotein D (gD) were used to determine in vitro functional activity and association with protection against lethal infection in a murine model of neonatal HSV disease. Antiviral neutralization activity of HSV was not associated with antibody-dependent cellular cytotoxicity (ADCC) activity to HSV-infected cells in vitro. In a model of high dose challenge (10(4) PFU), protection was not afforded by any antibody alone, but was by antibody plus human mononuclear cells, and highly associated with ADCC functional activity (P less than 0.001). In a low dose challenge model, neutralizing activity of antibody alone was associated with protection in vivo (P less than 0.001). Of the nine neutralizing epitopes of gD in vitro, eight were predicted surface regions. Four of the five epitopic sites of gD (2-21, 267-276, 288-297, and 303-312) that were determined to be important targets of ADCC and in vivo protection were also predicted to be surface regions. The only exception was the antiserum to region 52-61 which was predicted to be buried and also showed these activities. ADCC as well as neutralizing antibody activity are important in protection against neonatal HSV infection." @default.
• W2045241531 created "2016-06-24" @default.
• W2045241531 creator A5021361212 @default.
• W2045241531 creator A5022292484 @default.
• W2045241531 creator A5052295449 @default.
• W2045241531 creator A5084368441 @default.
• W2045241531 date "1990-07-01" @default.
• W2045241531 modified "2023-10-01" @default.
• W2045241531 title "Analysis of the role of antibody-dependent cellular cytotoxic antibody activity in murine neonatal herpes simplex virus infection with antibodies to synthetic peptides of glycoprotein D and monoclonal antibodies to glycoprotein B." @default.
• W2045241531 cites W1495740018 @default.
• W2045241531 cites W1501343112 @default.
• W2045241531 cites W150788899 @default.
• W2045241531 cites W1513562736 @default.
• W2045241531 cites W1514552728 @default.
• W2045241531 cites W1515503939 @default.
• W2045241531 cites W1535364173 @default.
• W2045241531 cites W1537838794 @default.
• W2045241531 cites W1605688513 @default.
• W2045241531 cites W1669021499 @default.
• W2045241531 cites W1796276420 @default.
• W2045241531 cites W1832377940 @default.
• W2045241531 cites W1840288476 @default.
• W2045241531 cites W1846652691 @default.
• W2045241531 cites W1850311918 @default.
• W2045241531 cites W1875826709 @default.
• W2045241531 cites W1892778052 @default.
• W2045241531 cites W1893731418 @default.
• W2045241531 cites W1925841472 @default.
• W2045241531 cites W1927054599 @default.
• W2045241531 cites W1949254894 @default.
• W2045241531 cites W1968465263 @default.
• W2045241531 cites W1974861780 @default.
• W2045241531 cites W1981644692 @default.
• W2045241531 cites W1981979611 @default.
• W2045241531 cites W1984412128 @default.
• W2045241531 cites W1988565921 @default.
• W2045241531 cites W2002932863 @default.
• W2045241531 cites W2009600945 @default.
• W2045241531 cites W2024223500 @default.
• W2045241531 cites W2043034797 @default.
• W2045241531 cites W2049317402 @default.
• W2045241531 cites W2061184354 @default.
• W2045241531 cites W2062604147 @default.
• W2045241531 cites W2069528963 @default.
• W2045241531 cites W2086241766 @default.
• W2045241531 cites W2100034740 @default.
• W2045241531 cites W2103077855 @default.
• W2045241531 cites W2103863471 @default.
• W2045241531 cites W2106539372 @default.
• W2045241531 cites W2107910903 @default.
• W2045241531 cites W2125012288 @default.
• W2045241531 cites W2145813509 @default.
• W2045241531 cites W2158523873 @default.
• W2045241531 cites W2296848948 @default.
• W2045241531 cites W2317582182 @default.
• W2045241531 cites W2320320272 @default.
• W2045241531 cites W2327242279 @default.
• W2045241531 cites W2332559639 @default.
• W2045241531 cites W2415896803 @default.
• W2045241531 cites W2417238422 @default.
• W2045241531 doi "https://doi.org/10.1172/jci114695" @default.
• W2045241531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/296717" @default.
• W2045241531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2164044" @default.
• W2045241531 hasPublicationYear "1990" @default.
• W2045241531 type Work @default.
• W2045241531 sameAs 2045241531 @default.
• W2045241531 citedByCount "53" @default.
• W2045241531 countsByYear W20452415312012 @default.
• W2045241531 countsByYear W20452415312016 @default.
• W2045241531 countsByYear W20452415312017 @default.
• W2045241531 countsByYear W20452415312018 @default.
• W2045241531 countsByYear W20452415312019 @default.
• W2045241531 countsByYear W20452415312020 @default.
• W2045241531 countsByYear W20452415312022 @default.
• W2045241531 countsByYear W20452415312023 @default.
• W2045241531 crossrefType "journal-article" @default.
• W2045241531 hasAuthorship W2045241531A5021361212 @default.
• W2045241531 hasAuthorship W2045241531A5022292484 @default.
• W2045241531 hasAuthorship W2045241531A5052295449 @default.
• W2045241531 hasAuthorship W2045241531A5084368441 @default.
• W2045241531 hasBestOaLocation W20452415311 @default.
• W2045241531 hasConcept C159047783 @default.
• W2045241531 hasConcept C159654299 @default.
• W2045241531 hasConcept C195616568 @default.
• W2045241531 hasConcept C203014093 @default.
• W2045241531 hasConcept C2522874641 @default.
• W2045241531 hasConcept C2779261636 @default.
• W2045241531 hasConcept C2781196997 @default.
• W2045241531 hasConcept C40677261 @default.
• W2045241531 hasConcept C542903549 @default.
• W2045241531 hasConcept C86803240 @default.
• W2045241531 hasConcept C91523082 @default.
• W2045241531 hasConcept C956191 @default.
• W2045241531 hasConceptScore W2045241531C159047783 @default.
• W2045241531 hasConceptScore W2045241531C159654299 @default.
• W2045241531 hasConceptScore W2045241531C195616568 @default.
• W2045241531 hasConceptScore W2045241531C203014093 @default.
• W2045241531 hasConceptScore W2045241531C2522874641 @default.

• next