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- W2045243107 abstract "The orderly progression of cells through the cell cycle is governed by genes encoding proteins transmitting positive (e.g., activated cyclin and cyclin-dependent kinases [Cdk]) and negative (e.g., inhibitors of Cdk) signals (Norbury and Nurse 1992; Reed 1992; Hunter 1993; Sherr 1993; Ron 1994). Dysregulation of these genes can lead to premature entry into the next phase of the cell cycle prior to completion of critical macromolecular events, including repair of DNA damage, and generate genomic instability and neoplastic transformation (Hartwell 1992). Negative regulation of the cell cycle occurs at G1 and G2 checkpoints (Hartwell and Weinert 1989; Pardee 1989; Hartwell 1992). Phosphorylation of the Rb protein by Cdk and the release of Rb-associated proteins, e.g., the transcription factor E2F, are correlated with the transition across the G1 checkpoint (Buchkovich et al. 1989; Chen et al. 1989; DeCaprio et al. 1989; Mihara et al. 1989; Helin et al. 1992; Kaelin et..." @default.
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- W2045243107 title "p16 INK4 Mutations and Altered Expression in Human Tumors and Cell Lines" @default.
- W2045243107 doi "https://doi.org/10.1101/sqb.1994.059.01.008" @default.
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