FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045247705> ?p ?o ?g. }

• W2045247705 endingPage "712" @default.
• W2045247705 startingPage "701" @default.
• W2045247705 abstract "N-terminal-ubiquitinylation (NTU) is a newly discovered protein degradation pathway initiated by ubiquitin-tagging of the N-terminal α-amino group. We have used data from recent genomic studies, especially those on humans, to up-date and re-interpret biochemical data to identify the sequence features associated with NTU. We compared a mini-proteome for which experimental protein sequence is available with large-scale genomic data. We conclude that N-α-acetylation involves less than 30%, and not the widely assumed 90%, of the proteins encoded by any higher eukaryote genome, greatly increasing thereby the number of possible targets for NTU-mediated degradation. Next, straightforward rules linking the first N-terminal residues of any nascent polypeptides to the nature of their processed N-termini are established and dedicated prediction tool is made available at http://www.isv.cnrs-gif.fr/Terminator/. We provide strong arguments indicating that the nature of the processed N-terminus is a major determinant factor of the half-life of the protein. We finally reveal that one third of the nuclear-encoded proteins starting with an unprocessed and unblocked methionine are at least one order of magnitude less stable than is average in higher eukaryotes. This appears to be the first common feature of proteins undergoing N-terminal ubiquitinylation. Hence, a pool of about 3000 proteins in each proteome could be unstable per se and tagged for rapid degradation via NTU." @default.
• W2045247705 created "2016-06-24" @default.
• W2045247705 creator A5072337283 @default.
• W2045247705 creator A5083236007 @default.
• W2045247705 creator A5091266792 @default.
• W2045247705 date "2005-08-01" @default.
• W2045247705 modified "2023-10-13" @default.
• W2045247705 title "Processed N-termini of mature proteins in higher eukaryotes and their major contribution to dynamic proteomics" @default.
• W2045247705 cites W1221688681 @default.
• W2045247705 cites W1479851678 @default.
• W2045247705 cites W1493816947 @default.
• W2045247705 cites W1518108212 @default.
• W2045247705 cites W1526449859 @default.
• W2045247705 cites W1528264894 @default.
• W2045247705 cites W1550151833 @default.
• W2045247705 cites W1557428740 @default.
• W2045247705 cites W1563308126 @default.
• W2045247705 cites W1574322319 @default.
• W2045247705 cites W1583799645 @default.
• W2045247705 cites W1597425465 @default.
• W2045247705 cites W1649950618 @default.
• W2045247705 cites W1777975802 @default.
• W2045247705 cites W1971579210 @default.
• W2045247705 cites W1975645593 @default.
• W2045247705 cites W1976099082 @default.
• W2045247705 cites W1981555577 @default.
• W2045247705 cites W1982537978 @default.
• W2045247705 cites W1983110751 @default.
• W2045247705 cites W1983345237 @default.
• W2045247705 cites W1987045539 @default.
• W2045247705 cites W1987467454 @default.
• W2045247705 cites W1991101546 @default.
• W2045247705 cites W1993839005 @default.
• W2045247705 cites W1998918910 @default.
• W2045247705 cites W2004500138 @default.
• W2045247705 cites W2005548849 @default.
• W2045247705 cites W2005633684 @default.
• W2045247705 cites W2005796547 @default.
• W2045247705 cites W2010671788 @default.
• W2045247705 cites W2011001101 @default.
• W2045247705 cites W2019672253 @default.
• W2045247705 cites W2021177388 @default.
• W2045247705 cites W2021363994 @default.
• W2045247705 cites W2024417910 @default.
• W2045247705 cites W2025636361 @default.
• W2045247705 cites W2027151805 @default.
• W2045247705 cites W2028964899 @default.
• W2045247705 cites W2030288452 @default.
• W2045247705 cites W2035452413 @default.
• W2045247705 cites W2041770258 @default.
• W2045247705 cites W2042096080 @default.
• W2045247705 cites W2043821463 @default.
• W2045247705 cites W2046290726 @default.
• W2045247705 cites W2046598590 @default.
• W2045247705 cites W2049928191 @default.
• W2045247705 cites W2051094352 @default.
• W2045247705 cites W2051681013 @default.
• W2045247705 cites W2052669949 @default.
• W2045247705 cites W2053632669 @default.
• W2045247705 cites W2054400465 @default.
• W2045247705 cites W2054483928 @default.
• W2045247705 cites W2059525103 @default.
• W2045247705 cites W2071056869 @default.
• W2045247705 cites W2071189076 @default.
• W2045247705 cites W2073852558 @default.
• W2045247705 cites W2076255097 @default.
• W2045247705 cites W2077817524 @default.
• W2045247705 cites W2080144028 @default.
• W2045247705 cites W2083348615 @default.
• W2045247705 cites W2085106552 @default.
• W2045247705 cites W2106691851 @default.
• W2045247705 cites W2111957555 @default.
• W2045247705 cites W2114070867 @default.
• W2045247705 cites W2114756704 @default.
• W2045247705 cites W2115167405 @default.
• W2045247705 cites W2115885986 @default.
• W2045247705 cites W2118419827 @default.
• W2045247705 cites W2122634675 @default.
• W2045247705 cites W2123781000 @default.
• W2045247705 cites W2126544665 @default.
• W2045247705 cites W2132897827 @default.
• W2045247705 cites W2140337827 @default.
• W2045247705 cites W2140558722 @default.
• W2045247705 cites W2148636018 @default.
• W2045247705 cites W2152458080 @default.
• W2045247705 cites W2154916254 @default.
• W2045247705 cites W2155350883 @default.
• W2045247705 cites W2166802900 @default.
• W2045247705 cites W2168847939 @default.
• W2045247705 cites W2171091522 @default.
• W2045247705 cites W2171371492 @default.
• W2045247705 cites W2176248001 @default.
• W2045247705 cites W2180080905 @default.
• W2045247705 cites W2317569972 @default.
• W2045247705 cites W2688325281 @default.
• W2045247705 doi "https://doi.org/10.1016/j.biochi.2005.03.011" @default.
• W2045247705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16054524" @default.
• W2045247705 hasPublicationYear "2005" @default.

• next