FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045249816> ?p ?o ?g. }

• W2045249816 endingPage "34332" @default.
• W2045249816 startingPage "34324" @default.
• W2045249816 abstract "Our understanding of the molecular mechanisms of T cell alloreactivity remains limited by the lack of systems for which both the T cell receptor allo- and cognate ligand are known. Here we provide evidence that a single alloreactive T cell receptor interacts with analogous structural regions of its cognate ligand, HLA-B*0801^FLRGRAYGL, as its allogeneic ligand, HLA-B*3501^KPIVVLHGY. The crystal structures of the binary peptide-major histocompatibility complexes show marked differences in the conformation of the heavy chains as well as the bound peptides. Nevertheless, both epitopes possess a prominent solvent-exposed aromatic residue at position 7 flanked by a small glycine at position 8 of the peptide determinant. Moreover, regions of close structural homology between the heavy chains of HLA B8 and HLA B35 coincided with regions that have previously been implicated in hot spots of T cell receptor recognition. The avidity of this human T cell receptor was also comparable for the allo- and cognate ligand, consistent with the modes of T cell receptor binding being broadly similar for these complexes. Collectively, it appears that highly focused structural mimicry against a diverse structural background provides a basis for the observed alloreactivity in this system. This cross-reactivity underpins the T cell degeneracy inherent in the limited mature T cell repertoire that must respond to a vast diversity of microbial antigens." @default.
• W2045249816 created "2016-06-24" @default.
• W2045249816 creator A5017677707 @default.
• W2045249816 creator A5023421955 @default.
• W2045249816 creator A5033140662 @default.
• W2045249816 creator A5039091374 @default.
• W2045249816 creator A5064870453 @default.
• W2045249816 creator A5071588466 @default.
• W2045249816 creator A5076921449 @default.
• W2045249816 creator A5081880237 @default.
• W2045249816 date "2006-11-01" @default.
• W2045249816 modified "2023-10-13" @default.
• W2045249816 title "Alloreactivity between Disparate Cognate and Allogeneic pMHC-I Complexes Is the Result of Highly Focused, Peptide-dependent Structural Mimicry" @default.
• W2045249816 cites W1593307100 @default.
• W2045249816 cites W1965342739 @default.
• W2045249816 cites W1965986127 @default.
• W2045249816 cites W1979262763 @default.
• W2045249816 cites W1985774274 @default.
• W2045249816 cites W1995017064 @default.
• W2045249816 cites W2002113738 @default.
• W2045249816 cites W2004618581 @default.
• W2045249816 cites W2007960013 @default.
• W2045249816 cites W2008557466 @default.
• W2045249816 cites W2013083986 @default.
• W2045249816 cites W2013874791 @default.
• W2045249816 cites W2029993034 @default.
• W2045249816 cites W2032428654 @default.
• W2045249816 cites W2036244559 @default.
• W2045249816 cites W2038840577 @default.
• W2045249816 cites W2047747639 @default.
• W2045249816 cites W2067060947 @default.
• W2045249816 cites W2068750493 @default.
• W2045249816 cites W2070530924 @default.
• W2045249816 cites W2071021373 @default.
• W2045249816 cites W2078699094 @default.
• W2045249816 cites W2082712562 @default.
• W2045249816 cites W2084492053 @default.
• W2045249816 cites W2101312482 @default.
• W2045249816 cites W2102571570 @default.
• W2045249816 cites W2106223181 @default.
• W2045249816 cites W2112997727 @default.
• W2045249816 cites W2124793991 @default.
• W2045249816 cites W2126134057 @default.
• W2045249816 cites W2129134079 @default.
• W2045249816 cites W2129274679 @default.
• W2045249816 cites W2132226411 @default.
• W2045249816 cites W2138431458 @default.
• W2045249816 cites W2144081223 @default.
• W2045249816 cites W2148382506 @default.
• W2045249816 cites W2150015291 @default.
• W2045249816 cites W2150650084 @default.
• W2045249816 cites W2154026406 @default.
• W2045249816 cites W2155687321 @default.
• W2045249816 cites W2161841913 @default.
• W2045249816 cites W2183601798 @default.
• W2045249816 cites W2321157084 @default.
• W2045249816 cites W4246566831 @default.
• W2045249816 doi "https://doi.org/10.1074/jbc.m606755200" @default.
• W2045249816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16963442" @default.
• W2045249816 hasPublicationYear "2006" @default.
• W2045249816 type Work @default.
• W2045249816 sameAs 2045249816 @default.
• W2045249816 citedByCount "55" @default.
• W2045249816 countsByYear W20452498162012 @default.
• W2045249816 countsByYear W20452498162013 @default.
• W2045249816 countsByYear W20452498162014 @default.
• W2045249816 countsByYear W20452498162015 @default.
• W2045249816 countsByYear W20452498162016 @default.
• W2045249816 countsByYear W20452498162017 @default.
• W2045249816 countsByYear W20452498162018 @default.
• W2045249816 countsByYear W20452498162019 @default.
• W2045249816 countsByYear W20452498162020 @default.
• W2045249816 countsByYear W20452498162021 @default.
• W2045249816 countsByYear W20452498162023 @default.
• W2045249816 crossrefType "journal-article" @default.
• W2045249816 hasAuthorship W2045249816A5017677707 @default.
• W2045249816 hasAuthorship W2045249816A5023421955 @default.
• W2045249816 hasAuthorship W2045249816A5033140662 @default.
• W2045249816 hasAuthorship W2045249816A5039091374 @default.
• W2045249816 hasAuthorship W2045249816A5064870453 @default.
• W2045249816 hasAuthorship W2045249816A5071588466 @default.
• W2045249816 hasAuthorship W2045249816A5076921449 @default.
• W2045249816 hasAuthorship W2045249816A5081880237 @default.
• W2045249816 hasBestOaLocation W20452498161 @default.
• W2045249816 hasConcept C116569031 @default.
• W2045249816 hasConcept C147483822 @default.
• W2045249816 hasConcept C170493617 @default.
• W2045249816 hasConcept C179223381 @default.
• W2045249816 hasConcept C188280979 @default.
• W2045249816 hasConcept C19317047 @default.
• W2045249816 hasConcept C195616568 @default.
• W2045249816 hasConcept C207936829 @default.
• W2045249816 hasConcept C2776090121 @default.
• W2045249816 hasConcept C2777119779 @default.
• W2045249816 hasConcept C2779281246 @default.
• W2045249816 hasConcept C54355233 @default.
• W2045249816 hasConcept C55493867 @default.
• W2045249816 hasConcept C86803240 @default.

• next