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- W2045254669 abstract "As applied to microscopy, the confocal technique is a powerful method that can non-invasively provide depth-resolved information on tissue because of its optical sectioning capability. Raman spectroscopy is a non-invasive optical technique that is very sensitive to the structure and conformation of biochemical constitutes. Combining these two distinct techniques can non-invasively provide depth-resolved biochemical information of the skin in vivo. In this paper, we present a novel confocal Raman spectrometer and preliminary results on in vivo Raman spectral measurements of mouse tumor model. A total of 255 Raman spectra were taken from 15 mice in vivo. We found that Raman spectra of different sub-layers in mouse skin differ significantly. Obvious spectral changes for the dermis were also observed between normal skin and skin immediately overlying subcutaneous tumor." @default.
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- W2045254669 date "2009-02-12" @default.
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- W2045254669 title "In vivo confocal Raman spectroscopy for skin disease diagnosis and characterization: preliminary results from mouse tumor models" @default.
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- W2045254669 doi "https://doi.org/10.1117/12.810953" @default.
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