Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045258843> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2045258843 endingPage "537" @default.
- W2045258843 startingPage "529" @default.
- W2045258843 abstract "Introduction Low-grade osteosarcoma encompasses parosteal osteosarcoma (POS) and low-grade central osteosarcoma (LCOS), with LCOS more rare than POS. LCOS is also more likely to be misdiagnosed and inappropriately treated with an intralesional procedure, due to its misleading radiological features and the overlap of its pathological characteristics with those of benign bone tumors. Therefore, as a diagnostic adjunct for LCOS, immunohistochemical assay with murine double-minute type 2 (MDM2) and cyclin-dependent kinase 4 (CDK4) have been tried with controversial results. We investigated (1) the clinical course and surgical outcome of LCOS, and (2) the diagnostic role of immune-histochemical markers (CDK4, MDM2) and their correlation with clinico-radiologic findings. Materials and methods We retrospectively reviewed 16 LCOS patients with regard to age, gender, tumor location, plain radiographic pattern, tumor volume, extraosseous extension, initial diagnosis, initial treatment, definitive diagnosis, definitive treatment, surgical margins, histochemical markers, and oncological outcome. Results Final survival status was continuous disease-free in 14, alive with disease in 1, and remaining 1 patient died of other cancer. Except for 1 patient who had not undergone excision of their primary lesion, no patients developed a local recurrence. Eight tumors (50 %) showed diffuse immunostaining for CDK4. Three of 8 tumors labeled for CDK4 were also positive for MDM2. Six (75 %) of 8 CDK4-positive tumors displayed lytic lesions on a plain radiograph; in contrast, 2 (33 %) of 6 tumors showing a sclerotic pattern on a plain radiograph were positive for CDK4. Conclusions The diagnosis of LCOS is challenging; however, if it is properly diagnosed, there is a high chance of a cure with wide excision alone. Positive immunostaining for CDK4 or MDM2 may be used as a diagnostic adjunct,although negative immunostaining cannot rule out this tumor. The clinical, radiological, and typical pathological findings are vital in raising the suspicion of this rare tumor." @default.
- W2045258843 created "2016-06-24" @default.
- W2045258843 creator A5013334833 @default.
- W2045258843 creator A5017614702 @default.
- W2045258843 creator A5022103198 @default.
- W2045258843 creator A5026100967 @default.
- W2045258843 creator A5026924708 @default.
- W2045258843 creator A5042940999 @default.
- W2045258843 creator A5054662098 @default.
- W2045258843 creator A5069904190 @default.
- W2045258843 date "2015-01-01" @default.
- W2045258843 modified "2023-10-16" @default.
- W2045258843 title "Clinical outcome of low-grade central osteosarcoma and role of CDK4 and MDM2 immunohistochemistry as a diagnostic adjunct" @default.
- W2045258843 cites W142947756 @default.
- W2045258843 cites W1964824855 @default.
- W2045258843 cites W1971623461 @default.
- W2045258843 cites W1979413024 @default.
- W2045258843 cites W2001972366 @default.
- W2045258843 cites W2005938627 @default.
- W2045258843 cites W2047102720 @default.
- W2045258843 cites W2051905784 @default.
- W2045258843 cites W2062763841 @default.
- W2045258843 cites W2069122414 @default.
- W2045258843 cites W2074593442 @default.
- W2045258843 cites W2079763775 @default.
- W2045258843 cites W2080247106 @default.
- W2045258843 cites W2087582057 @default.
- W2045258843 cites W2092061242 @default.
- W2045258843 cites W2324803135 @default.
- W2045258843 cites W4236686570 @default.
- W2045258843 doi "https://doi.org/10.1007/s00776-015-0701-0" @default.
- W2045258843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25740728" @default.
- W2045258843 hasPublicationYear "2015" @default.
- W2045258843 type Work @default.
- W2045258843 sameAs 2045258843 @default.
- W2045258843 citedByCount "13" @default.
- W2045258843 countsByYear W20452588432016 @default.
- W2045258843 countsByYear W20452588432017 @default.
- W2045258843 countsByYear W20452588432018 @default.
- W2045258843 countsByYear W20452588432020 @default.
- W2045258843 countsByYear W20452588432021 @default.
- W2045258843 countsByYear W20452588432022 @default.
- W2045258843 crossrefType "journal-article" @default.
- W2045258843 hasAuthorship W2045258843A5013334833 @default.
- W2045258843 hasAuthorship W2045258843A5017614702 @default.
- W2045258843 hasAuthorship W2045258843A5022103198 @default.
- W2045258843 hasAuthorship W2045258843A5026100967 @default.
- W2045258843 hasAuthorship W2045258843A5026924708 @default.
- W2045258843 hasAuthorship W2045258843A5042940999 @default.
- W2045258843 hasAuthorship W2045258843A5054662098 @default.
- W2045258843 hasAuthorship W2045258843A5069904190 @default.
- W2045258843 hasConcept C126838900 @default.
- W2045258843 hasConcept C142724271 @default.
- W2045258843 hasConcept C204232928 @default.
- W2045258843 hasConcept C2777760704 @default.
- W2045258843 hasConcept C2781156865 @default.
- W2045258843 hasConcept C36454342 @default.
- W2045258843 hasConcept C71924100 @default.
- W2045258843 hasConceptScore W2045258843C126838900 @default.
- W2045258843 hasConceptScore W2045258843C142724271 @default.
- W2045258843 hasConceptScore W2045258843C204232928 @default.
- W2045258843 hasConceptScore W2045258843C2777760704 @default.
- W2045258843 hasConceptScore W2045258843C2781156865 @default.
- W2045258843 hasConceptScore W2045258843C36454342 @default.
- W2045258843 hasConceptScore W2045258843C71924100 @default.
- W2045258843 hasIssue "3" @default.
- W2045258843 hasLocation W20452588431 @default.
- W2045258843 hasLocation W20452588432 @default.
- W2045258843 hasOpenAccess W2045258843 @default.
- W2045258843 hasPrimaryLocation W20452588431 @default.
- W2045258843 hasRelatedWork W1568701304 @default.
- W2045258843 hasRelatedWork W2295554611 @default.
- W2045258843 hasRelatedWork W2356088282 @default.
- W2045258843 hasRelatedWork W2374603938 @default.
- W2045258843 hasRelatedWork W2390117547 @default.
- W2045258843 hasRelatedWork W2414183708 @default.
- W2045258843 hasRelatedWork W2891593192 @default.
- W2045258843 hasRelatedWork W3031219381 @default.
- W2045258843 hasRelatedWork W3032601271 @default.
- W2045258843 hasRelatedWork W4250549352 @default.
- W2045258843 hasVolume "20" @default.
- W2045258843 isParatext "false" @default.
- W2045258843 isRetracted "false" @default.
- W2045258843 magId "2045258843" @default.
- W2045258843 workType "article" @default.