FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045259007> ?p ?o ?g. }

• W2045259007 endingPage "128" @default.
• W2045259007 startingPage "122" @default.
• W2045259007 abstract "Methamphetamine (MA) use has been shown to decrease n-acetyl-aspartate (NAA), a marker of neuronal integrity and viability, on 1H magnetic resonance spectroscopy (1H-MRS). However, little work has compared 1H-MRS in MA dependent individuals and MA dependent individuals with MA induced psychotic disorder (MAP). Twenty six participants with MA dependence (sixteen without psychosis, ten with psychosis — MAP) and nineteen healthy controls underwent 2D-chemical shift imaging 1H-MRS, which included voxels in the anterior cingulate cortices (ACC), dorsolateral prefrontal cortices (DLPFC), and frontal white matter. We compared metabolite concentrations relative to phosphocreatine + creatine (PCr + Cr) for n-acetyl-aspartate (NAA), n-acetyl-aspartate + n-acetyl-aspartyl-glutamate (NAA + NAAG), glutamate (Glu), glutamate + glutamine (Glu + Gln), myo-inositol, and glycerophosphocholine + phosphocholine (GPC + PCh) across groups. The MA groups showed significantly decreased relative NAA metabolite concentrations for right ACC and right DLPFC, compared with control group. The MA dependent group only showed significantly decreased choline metabolites for right DLPFC, compared with control group. The MAP group's relative NAA metabolite concentrations were significantly correlated with age of initial use and duration of MA use, these correlates were not apparent in MA dependent group. MA use is associated with decreased neuronal integrity and viability, specifically in the right ACC and right DLPFC. MA dependence showed active neurodegeneration in the right DLPFC, this was not apparent in the MAP group and may be related to the use of antipsychotic medication in the MAP group. The effects of MA use in MAP suggest that age of initial use presents a mismatch of neuronal plasticity, in frontal white vs. gray matter and duration of use relates to decreased neuronal integrity and viability. Further study is warranted from this initial study of 1H-MRS in MAP, in particular longitudinal assessment of these individuals both neurobiologically (1H-MRS) and clinically — to determine disease progression." @default.
• W2045259007 created "2016-06-24" @default.
• W2045259007 creator A5021539154 @default.
• W2045259007 creator A5035794371 @default.
• W2045259007 creator A5041456040 @default.
• W2045259007 creator A5050600083 @default.
• W2045259007 creator A5050824346 @default.
• W2045259007 creator A5065265187 @default.
• W2045259007 creator A5073216705 @default.
• W2045259007 date "2014-03-01" @default.
• W2045259007 modified "2023-09-30" @default.
• W2045259007 title "1H-magnetic resonance spectroscopy (1H-MRS) in methamphetamine dependence and methamphetamine induced psychosis" @default.
• W2045259007 cites W142630271 @default.
• W2045259007 cites W1921333563 @default.
• W2045259007 cites W1975922521 @default.
• W2045259007 cites W1980277972 @default.
• W2045259007 cites W1982587345 @default.
• W2045259007 cites W1982977182 @default.
• W2045259007 cites W1986325442 @default.
• W2045259007 cites W1988366576 @default.
• W2045259007 cites W1989878117 @default.
• W2045259007 cites W1990342267 @default.
• W2045259007 cites W1990906553 @default.
• W2045259007 cites W1992372396 @default.
• W2045259007 cites W1998679999 @default.
• W2045259007 cites W2018703700 @default.
• W2045259007 cites W2022069481 @default.
• W2045259007 cites W2025162057 @default.
• W2045259007 cites W2029160141 @default.
• W2045259007 cites W2035060597 @default.
• W2045259007 cites W2038979894 @default.
• W2045259007 cites W2039864610 @default.
• W2045259007 cites W2042162632 @default.
• W2045259007 cites W2050219143 @default.
• W2045259007 cites W2055740037 @default.
• W2045259007 cites W2063003023 @default.
• W2045259007 cites W2073663271 @default.
• W2045259007 cites W2083917106 @default.
• W2045259007 cites W2084701866 @default.
• W2045259007 cites W2087723693 @default.
• W2045259007 cites W2091584492 @default.
• W2045259007 cites W2093911340 @default.
• W2045259007 cites W2116594433 @default.
• W2045259007 cites W2117312470 @default.
• W2045259007 cites W2128389358 @default.
• W2045259007 cites W2131410584 @default.
• W2045259007 cites W2132440146 @default.
• W2045259007 cites W2137243997 @default.
• W2045259007 cites W2137640133 @default.
• W2045259007 cites W2138996831 @default.
• W2045259007 cites W2140606211 @default.
• W2045259007 cites W2141712052 @default.
• W2045259007 cites W2148039941 @default.
• W2045259007 cites W2151238901 @default.
• W2045259007 cites W2155712242 @default.
• W2045259007 cites W2167284547 @default.
• W2045259007 cites W2312740478 @default.
• W2045259007 doi "https://doi.org/10.1016/j.schres.2014.01.029" @default.
• W2045259007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24529366" @default.
• W2045259007 hasPublicationYear "2014" @default.
• W2045259007 type Work @default.
• W2045259007 sameAs 2045259007 @default.
• W2045259007 citedByCount "40" @default.
• W2045259007 countsByYear W20452590072014 @default.
• W2045259007 countsByYear W20452590072015 @default.
• W2045259007 countsByYear W20452590072016 @default.
• W2045259007 countsByYear W20452590072017 @default.
• W2045259007 countsByYear W20452590072018 @default.
• W2045259007 countsByYear W20452590072019 @default.
• W2045259007 countsByYear W20452590072020 @default.
• W2045259007 countsByYear W20452590072021 @default.
• W2045259007 countsByYear W20452590072022 @default.
• W2045259007 countsByYear W20452590072023 @default.
• W2045259007 crossrefType "journal-article" @default.
• W2045259007 hasAuthorship W2045259007A5021539154 @default.
• W2045259007 hasAuthorship W2045259007A5035794371 @default.
• W2045259007 hasAuthorship W2045259007A5041456040 @default.
• W2045259007 hasAuthorship W2045259007A5050600083 @default.
• W2045259007 hasAuthorship W2045259007A5050824346 @default.
• W2045259007 hasAuthorship W2045259007A5065265187 @default.
• W2045259007 hasAuthorship W2045259007A5073216705 @default.
• W2045259007 hasConcept C118552586 @default.
• W2045259007 hasConcept C126322002 @default.
• W2045259007 hasConcept C126838900 @default.
• W2045259007 hasConcept C134018914 @default.
• W2045259007 hasConcept C143409427 @default.
• W2045259007 hasConcept C15744967 @default.
• W2045259007 hasConcept C169760540 @default.
• W2045259007 hasConcept C169900460 @default.
• W2045259007 hasConcept C170493617 @default.
• W2045259007 hasConcept C185592680 @default.
• W2045259007 hasConcept C2777477808 @default.
• W2045259007 hasConcept C2778402161 @default.
• W2045259007 hasConcept C2778626300 @default.
• W2045259007 hasConcept C2779349466 @default.
• W2045259007 hasConcept C2779727114 @default.
• W2045259007 hasConcept C2779896295 @default.
• W2045259007 hasConcept C2780376393 @default.

• next