FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045266309> ?p ?o ?g. }

• W2045266309 endingPage "261" @default.
• W2045266309 startingPage "249" @default.
• W2045266309 abstract "Cyclic ADP-ribose is an important calcium mobilizing metabolite produced by the ADP-ribosyl cyclase (cyclases) family of enzymes. Three evolutionarily conserved ADP-ribosyl cyclase superfamily members have been identified, one from the invertebrate Aplysia californica and two from mammalian tissues, CD38 and CD157. CD38 regulates calcium signaling in a number of cell types, and it was recently shown that cyclic ADP-ribose produced by CD38 modulates calcium mobilization induced upon chemokine receptor engagement. Excitingly, because immunocytes deficient in CD38 are unable to migrate to inflammatory sites in vivo, this enzyme has now become an attractive target for drug development. To rationally design inhibitors it is critical to understand the mechanism(s) by which CD38 catalyzes the transformation of its substrate NAD+ into cyclic ADP-ribose. Likewise, it is necessary to identify the CD38 substrate-binding site. Importantly, significant progress has been made in these two areas and much is now known about the structure and enzymology of CD38 and the other ADP-ribosyl cyclase superfamily members. In this review, we will outline the critical data demonstrating a role for CD38 in regulating calcium mobilization in mammalian cells. We will also describe the crystallographic data and site-directed mutagenesis studies that have helped to elucidate the CD38 structure and the identification of its active site and key catalytic residues. Finally, we will address the important advances in our understanding of the kinetic and molecular mechanisms that control cyclic ADP-ribose production by CD38. Keywords: Enzymology, ADP-ribosyl, immunocytes, mutagenesis" @default.
• W2045266309 created "2016-06-24" @default.
• W2045266309 creator A5058323196 @default.
• W2045266309 creator A5060797804 @default.
• W2045266309 date "2004-05-01" @default.
• W2045266309 modified "2023-09-26" @default.
• W2045266309 title "Structure and Enzymology of ADP-ribosyl Cyclases: Conserved Enzymes that Produce Multiple Calcium Mobilizing Metabolites" @default.
• W2045266309 doi "https://doi.org/10.2174/1566524043360708" @default.
• W2045266309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15101683" @default.
• W2045266309 hasPublicationYear "2004" @default.
• W2045266309 type Work @default.
• W2045266309 sameAs 2045266309 @default.
• W2045266309 citedByCount "103" @default.
• W2045266309 countsByYear W20452663092012 @default.
• W2045266309 countsByYear W20452663092013 @default.
• W2045266309 countsByYear W20452663092014 @default.
• W2045266309 countsByYear W20452663092015 @default.
• W2045266309 countsByYear W20452663092016 @default.
• W2045266309 countsByYear W20452663092017 @default.
• W2045266309 countsByYear W20452663092018 @default.
• W2045266309 countsByYear W20452663092019 @default.
• W2045266309 countsByYear W20452663092020 @default.
• W2045266309 countsByYear W20452663092021 @default.
• W2045266309 countsByYear W20452663092022 @default.
• W2045266309 crossrefType "journal-article" @default.
• W2045266309 hasAuthorship W2045266309A5058323196 @default.
• W2045266309 hasAuthorship W2045266309A5060797804 @default.
• W2045266309 hasConcept C10205521 @default.
• W2045266309 hasConcept C104317684 @default.
• W2045266309 hasConcept C159912055 @default.
• W2045266309 hasConcept C16318435 @default.
• W2045266309 hasConcept C181199279 @default.
• W2045266309 hasConcept C185592680 @default.
• W2045266309 hasConcept C2777336126 @default.
• W2045266309 hasConcept C2780069284 @default.
• W2045266309 hasConcept C28328180 @default.
• W2045266309 hasConcept C501734568 @default.
• W2045266309 hasConcept C55493867 @default.
• W2045266309 hasConcept C75520062 @default.
• W2045266309 hasConcept C86803240 @default.
• W2045266309 hasConcept C95444343 @default.
• W2045266309 hasConceptScore W2045266309C10205521 @default.
• W2045266309 hasConceptScore W2045266309C104317684 @default.
• W2045266309 hasConceptScore W2045266309C159912055 @default.
• W2045266309 hasConceptScore W2045266309C16318435 @default.
• W2045266309 hasConceptScore W2045266309C181199279 @default.
• W2045266309 hasConceptScore W2045266309C185592680 @default.
• W2045266309 hasConceptScore W2045266309C2777336126 @default.
• W2045266309 hasConceptScore W2045266309C2780069284 @default.
• W2045266309 hasConceptScore W2045266309C28328180 @default.
• W2045266309 hasConceptScore W2045266309C501734568 @default.
• W2045266309 hasConceptScore W2045266309C55493867 @default.
• W2045266309 hasConceptScore W2045266309C75520062 @default.
• W2045266309 hasConceptScore W2045266309C86803240 @default.
• W2045266309 hasConceptScore W2045266309C95444343 @default.
• W2045266309 hasIssue "3" @default.
• W2045266309 hasLocation W20452663091 @default.
• W2045266309 hasLocation W20452663092 @default.
• W2045266309 hasOpenAccess W2045266309 @default.
• W2045266309 hasPrimaryLocation W20452663091 @default.
• W2045266309 hasRelatedWork W1972522834 @default.
• W2045266309 hasRelatedWork W1993624419 @default.
• W2045266309 hasRelatedWork W2040751094 @default.
• W2045266309 hasRelatedWork W2082340361 @default.
• W2045266309 hasRelatedWork W2145986636 @default.
• W2045266309 hasRelatedWork W2219871311 @default.
• W2045266309 hasRelatedWork W2463553255 @default.
• W2045266309 hasRelatedWork W309933625 @default.
• W2045266309 hasRelatedWork W384600175 @default.
• W2045266309 hasRelatedWork W4249430376 @default.
• W2045266309 hasVolume "4" @default.
• W2045266309 isParatext "false" @default.
• W2045266309 isRetracted "false" @default.
• W2045266309 magId "2045266309" @default.
• W2045266309 workType "article" @default.