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• W2045267269 abstract "Electrophysiological and pharmacological properties of the pinacidil-induced K+ currents in isolated cells from pig urethra were investigated using patch-clamp techniques. Pinacidil (100 microM) induced an outward current at -50 mV which gradually decreased. Under current-clamp conditions, 100 microM pinacidil induced a hyperpolarization that was sustained. This suggests that activation of only a few channels can hyperpolarize the membrane. At a holding potential of -50 mV, glibenclamide inhibited the pinacidil-induced current with a single exponential time course. Unitary current recordings in symmetrical 140 mM K+ conditions demonstrated that pinacidil activates a 43-pS, glibenclamide-sensitive K+ channel (i.e. K(ATP) channel). Analysis of the basal noise of the pinacidil-induced macroscopic currents from -90 mV to -30 mV yielded estimates of channel conductance (6 pS) which were much smaller, and probably an underestimate. These results indicate that pinacidil induces a glibenclamide-sensitive K+ current through only one type of K+ channel (K(ATP) channel) in pig urethra." @default.
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• W2045267269 date "2000-11-01" @default.
• W2045267269 modified "2023-10-14" @default.
• W2045267269 title "Possible Underestimation of the Channel Conductance Underlying Pinacidil-induced K+ Currents Using Noise Analysis in Pig Urethral Myocytes" @default.
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• W2045267269 doi "https://doi.org/10.1211/0022357001777397" @default.
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