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- W2045271625 abstract "The mucin 1 (MUC1) oncoprotein is aberrantly overexpressed in human breast cancers. Although MUC1 modulates the activity of estrogen receptor α (ER), there is no information regarding the effects of MUC1 on global gene expression patterns and the potential role of MUC1-induced genes in predicting outcome for breast cancer patients. We have developed an experimental model of MUC1-induced transformation that has identified the activation of genes involved in cholesterol and fatty acid metabolism. A 38-gene set of experimentally derived MUC1-induced genes associated with lipid metabolism was applied to the analysis of ER + breast cancer patients treated with tamoxifen. The results obtained from 2 independent databases demonstrate that patients overexpressing MUC1 and the lipid metabolic pathways are at significantly higher risk for death and recurrence/distant metastasis. By contrast, these genes were not predictive in untreated patients. Furthermore, a positive correlation was found between expression of the 38-gene set and the ER signaling pathway. These findings indicate that ( i ) MUC1 regulates cholesterol and fatty acid metabolism, and ( ii ) activation of these pathways in ER + breast cancers predicts failure to tamoxifen treatment." @default.
- W2045271625 created "2016-06-24" @default.
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- W2045271625 date "2009-04-07" @default.
- W2045271625 modified "2023-09-23" @default.
- W2045271625 title "MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment" @default.
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- W2045271625 doi "https://doi.org/10.1073/pnas.0812029106" @default.
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