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- W2045274672 abstract "We examined the expression of peroxisome proliferator‐activated receptors (PPARs) and the role of PPARs in cytokine production in mouse bone marrow‐derived mast cells (mBMMCs). mBMMCs expressed PPARβ strongly and γ slightly, but not α. Activation of mBMMCs with antigen or calcium ionophore resulted in the increased expression of PPARγ mRNA specifically. 15‐Deoxy‐Δ 12,14 ‐prostaglandin J 2 (15d‐PGJ 2 ) and troglitazone, all PPARγ ligands, attenuated the antigen‐induced cytokine production by mBMMCs. Carbaprostacyclin, a PPARβ ligand, also inhibited cytokine production, whereas PPARα ligands did not. These results suggest that PPARβ and γ might be included in the negative regulation of mast cell activation." @default.
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- W2045274672 date "2000-02-07" @default.
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- W2045274672 title "Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells" @default.
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- W2045274672 doi "https://doi.org/10.1016/s0014-5793(00)01169-8" @default.
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