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• W2045278666 abstract "Background: The incidence of chronic obstructive pulmonary disease (COPD) is little investigated. This study assessed the incidence of a self-reported physician's diagnosis of chronic bronchitis and/or emphysema (CBE) and/or COPD (CBE/COPD), and investigated the effects of a family history of CBE in 1992 and change in smoking habits (assessed in 1992 and 2000) on this incidence.Methods: A follow-up study in 2000 of 4933 subjects who responded to a respiratory questionnaire study in 1992 was performed. Response rate was 86.8%. Odds ratios (ORs) for incident cases of CBE/COPD were calculated by multiple logistic regression.Results: The cumulative incidence of a physician's diagnosis of CBE/COPD was 2.9%. A family history of CBE predicted incident cases of CBE/COPD, OR 2.7 (95% CI 1.5–5.1). Also continuous smoking, relapse into smoking, or having stopped smoking between 1992 and 2000 had elevated ORs for incident cases of CBE/COPD, 2.6 (1.4–4.7), 7.2 (2.7–18.7), and 2.6 (1.3–5.3), while the OR for ex-smoking in 1992 as well as 2000 was 0.9 (0.4–1.8).Conclusions: A family history of CBE increases the risk for development of CBE/COPD. Sustained smoking cessation over many years may be required to significantly reduce the risk of developing CBE/COPD." @default.
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• W2045278666 date "2004-03-01" @default.
• W2045278666 modified "2023-10-16" @default.
• W2045278666 title "Influence of family history and smoking habits on the incidence of self-reported physician's diagnosis of COPD" @default.
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• W2045278666 doi "https://doi.org/10.1016/j.rmed.2003.10.006" @default.
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