Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045283250> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2045283250 endingPage "752" @default.
- W2045283250 startingPage "748" @default.
- W2045283250 abstract "<h3>Background/aims</h3> Chronic natural killer lymphocytosis (CNKL) has been associated with systemic autoimmunity; however, its association with scleritis or ocular autoimmunity has not been characterised. The natural killer (NK) cell function and immunophenotype of a patient with CNKL who developed bilateral scleritis and multiple systemic autoimmune findings were evaluated. <h3>Methods</h3> The ophthalmic records of a patient with CNKL and scleritis were reviewed over a 6-year period. Flow cytometry was performed to evaluate T cell, NK and B cell populations. NK cellular functions (ie, NK cytotoxicity and cytokine/chemokine production following interleukin 2 (IL2) stimulation) were evaluated. <h3>Results</h3> A 56-year-old woman with vitiligo, psoriatic arthritis, thyroiditis, erythema nodosum, bilateral anterior scleritis and Sjogren syndrome was managed with multiple immunosuppressive medications, including prednisone, mycophenolate mofetil and methotrexate. Flow cytometry showed a persistent elevation of CD56<sup>+</sup>CD3<sup>−</sup> NK cells greater than 40%, which was consistent with CNKL. NK cell cytotoxicity assay identified a deficiency of K562 cell lysis in the patient (1.46 mean-fold greater in control vs patient). NK cytokine/chemokine production following IL2 stimulation was also deficient (2.5–32.5-fold greater in control). Cytokines/chemokines assessed included pro-inflammatory (interferon γ, tumor necrosis factor α, IL1, monocyte chemotactic protein 1) and immunoregulatory cytokines (IL4, IL5 and IL10). An abnormal elevation of TCRα/β<sup>+</sup> CD3<sup>+</sup>CD4<sup>−</sup>CD8<sup>−</sup> T cells suggestive of autoimmune lymphoproliferative syndrome was observed; however, apoptosis dysfunction was not found. <h3>Conclusion</h3> The association of increased but dysfunctional NK cells in the context of multiple systemic and ocular manifestations suggests a role of NK cells in the pathogenesis of our patient9s disease. Further studies regarding NK cell dysfunction and ocular autoimmunity are needed." @default.
- W2045283250 created "2016-06-24" @default.
- W2045283250 creator A5004235114 @default.
- W2045283250 creator A5015850690 @default.
- W2045283250 creator A5026555428 @default.
- W2045283250 creator A5041721692 @default.
- W2045283250 creator A5047423695 @default.
- W2045283250 creator A5054664757 @default.
- W2045283250 creator A5060449251 @default.
- W2045283250 creator A5087891270 @default.
- W2045283250 date "2010-05-27" @default.
- W2045283250 modified "2023-09-26" @default.
- W2045283250 title "Scleritis and multiple systemic autoimmune manifestations in chronic natural killer cell lymphocytosis associated with elevated TCR / +CD3+CD4-CD8- double-negative T cells" @default.
- W2045283250 cites W1830526871 @default.
- W2045283250 cites W1967816370 @default.
- W2045283250 cites W1976911150 @default.
- W2045283250 cites W1977071217 @default.
- W2045283250 cites W1981858084 @default.
- W2045283250 cites W1984345266 @default.
- W2045283250 cites W2011324112 @default.
- W2045283250 cites W2020957993 @default.
- W2045283250 cites W2023441660 @default.
- W2045283250 cites W2045144251 @default.
- W2045283250 cites W2057970527 @default.
- W2045283250 cites W2076657253 @default.
- W2045283250 cites W2080601697 @default.
- W2045283250 cites W2083527679 @default.
- W2045283250 cites W2094335508 @default.
- W2045283250 cites W2101409687 @default.
- W2045283250 cites W2113209831 @default.
- W2045283250 cites W2120081611 @default.
- W2045283250 cites W2134506320 @default.
- W2045283250 cites W2166429754 @default.
- W2045283250 cites W2220195887 @default.
- W2045283250 cites W2413989434 @default.
- W2045283250 cites W248162401 @default.
- W2045283250 cites W69242113 @default.
- W2045283250 doi "https://doi.org/10.1136/bjo.2009.171264" @default.
- W2045283250 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3172679" @default.
- W2045283250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20508050" @default.
- W2045283250 hasPublicationYear "2010" @default.
- W2045283250 type Work @default.
- W2045283250 sameAs 2045283250 @default.
- W2045283250 citedByCount "9" @default.
- W2045283250 countsByYear W20452832502012 @default.
- W2045283250 countsByYear W20452832502013 @default.
- W2045283250 countsByYear W20452832502015 @default.
- W2045283250 countsByYear W20452832502019 @default.
- W2045283250 countsByYear W20452832502021 @default.
- W2045283250 countsByYear W20452832502022 @default.
- W2045283250 countsByYear W20452832502023 @default.
- W2045283250 crossrefType "journal-article" @default.
- W2045283250 hasAuthorship W2045283250A5004235114 @default.
- W2045283250 hasAuthorship W2045283250A5015850690 @default.
- W2045283250 hasAuthorship W2045283250A5026555428 @default.
- W2045283250 hasAuthorship W2045283250A5041721692 @default.
- W2045283250 hasAuthorship W2045283250A5047423695 @default.
- W2045283250 hasAuthorship W2045283250A5054664757 @default.
- W2045283250 hasAuthorship W2045283250A5060449251 @default.
- W2045283250 hasAuthorship W2045283250A5087891270 @default.
- W2045283250 hasBestOaLocation W20452832502 @default.
- W2045283250 hasConcept C203014093 @default.
- W2045283250 hasConcept C2776194053 @default.
- W2045283250 hasConcept C2781053147 @default.
- W2045283250 hasConcept C71924100 @default.
- W2045283250 hasConceptScore W2045283250C203014093 @default.
- W2045283250 hasConceptScore W2045283250C2776194053 @default.
- W2045283250 hasConceptScore W2045283250C2781053147 @default.
- W2045283250 hasConceptScore W2045283250C71924100 @default.
- W2045283250 hasIssue "6" @default.
- W2045283250 hasLocation W20452832501 @default.
- W2045283250 hasLocation W20452832502 @default.
- W2045283250 hasLocation W20452832503 @default.
- W2045283250 hasLocation W20452832504 @default.
- W2045283250 hasOpenAccess W2045283250 @default.
- W2045283250 hasPrimaryLocation W20452832501 @default.
- W2045283250 hasRelatedWork W1506200166 @default.
- W2045283250 hasRelatedWork W1995515455 @default.
- W2045283250 hasRelatedWork W2039318446 @default.
- W2045283250 hasRelatedWork W2080531066 @default.
- W2045283250 hasRelatedWork W2748952813 @default.
- W2045283250 hasRelatedWork W2899084033 @default.
- W2045283250 hasRelatedWork W3032375762 @default.
- W2045283250 hasRelatedWork W3108674512 @default.
- W2045283250 hasRelatedWork W3186345860 @default.
- W2045283250 hasRelatedWork W3205595427 @default.
- W2045283250 hasVolume "94" @default.
- W2045283250 isParatext "false" @default.
- W2045283250 isRetracted "false" @default.
- W2045283250 magId "2045283250" @default.
- W2045283250 workType "article" @default.