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- W2045291331 abstract "Abstract A four step degradation of the C8 ethyl ketone of apicidin provided a route to the C6 aldehyde intermediate and several mechanism-based transition state inhibitors of histone deacetylase. The compounds generated herein delineate the significance of apicidin's side chain, highlighted by the high affinity C8 aldehyde and C8-keto-9,10-epoxide analogs of apicidin." @default.
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- W2045291331 date "2000-10-01" @default.
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- W2045291331 title "Design and synthesis of histone deacetylase inhibitors: the development of apicidin transition state analogs" @default.
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- W2045291331 doi "https://doi.org/10.1016/s0040-4039(00)01366-6" @default.
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