FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045292004> ?p ?o ?g. }

• W2045292004 endingPage "310" @default.
• W2045292004 startingPage "305" @default.
• W2045292004 abstract "Objectives The relationship of p53 mutations as analyzed immunohistochemically to radiation response and therapeutic outcome was examined in a cohort of 301 patients with muscle-invasive transitional cell carcinoma of the bladder treated relatively uniformly with preoperative radiotherapy (50 Cy in 25 fractions) 4 to 6 weeks prior to radical cystectomy. Methods Adequate formalin-fixed paraffin-embedded archival tissue for the immunohistochemical staining of p53 using antibody DO1 was obtained in 109 patients. The median follow-up for those living was 91 months. Results. Overall, p53 staining was positive in 56% of the cases, with 60% positive in Stage T2 (n = 48), 42% in Stage T3a (n = 31), and 63% in Stage T3b (n = 30). Overexpression of p53 did not correlate with actuarial local control, distant metastasis freedom, disease freedom, or overall survival. However, significant associations were seen when these analyses were limited to patients with clinical Stage T3b disease. In this subgroup, the actuarial 5-year rates for patients with p53 positively and negatively stained tumors were 55% and 100%, respectively, for distant metastasis freedom (P = 0.01), 51 % and 91 % for disease freedom (P = 0.04), and 32% and 91 % for overall survival (P = 0.006). Cox proportional hazards models that included p53 staining and other prognostic factors of significance in the univariate analyses revealed p53 to be independently predictive of survival for patients with Stage T3b disease. Conclusions The prognostic value of p53 immunostaining rested with Stage T3b patients. Although no correlations were found with radiation response, p53 positivity in this subgroup was associated with a higher rate of distant metastasis and reduced overall survival. For these patients, p53 negativity would indicate that aggressive local treatment (that is, preoperative radiotherapy and cystectomy) is sufficient, whereas p53 positivity would indicate that multiagent chemotherapy is required because of the increased risk of distant metastasis." @default.
• W2045292004 created "2016-06-24" @default.
• W2045292004 creator A5002737792 @default.
• W2045292004 creator A5025147400 @default.
• W2045292004 creator A5046668269 @default.
• W2045292004 creator A5054759359 @default.
• W2045292004 creator A5063389942 @default.
• W2045292004 creator A5064171627 @default.
• W2045292004 creator A5069116689 @default.
• W2045292004 creator A5074455927 @default.
• W2045292004 date "1996-03-01" @default.
• W2045292004 modified "2023-10-18" @default.
• W2045292004 title "Prognostic value of p53 in muscle-invasive bladder cancer treated with preoperative radiotherapy" @default.
• W2045292004 cites W1970613165 @default.
• W2045292004 cites W1975102863 @default.
• W2045292004 cites W1979319210 @default.
• W2045292004 cites W1987466655 @default.
• W2045292004 cites W2061744151 @default.
• W2045292004 cites W2073584782 @default.
• W2045292004 cites W2081894694 @default.
• W2045292004 cites W2095774113 @default.
• W2045292004 cites W2109609879 @default.
• W2045292004 cites W2128846890 @default.
• W2045292004 cites W2147242002 @default.
• W2045292004 cites W2149287328 @default.
• W2045292004 cites W2155877820 @default.
• W2045292004 cites W2177584245 @default.
• W2045292004 cites W2318856916 @default.
• W2045292004 cites W4245844897 @default.
• W2045292004 cites W4248766838 @default.
• W2045292004 doi "https://doi.org/10.1016/s0090-4295(99)80443-9" @default.
• W2045292004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8633392" @default.
• W2045292004 hasPublicationYear "1996" @default.
• W2045292004 type Work @default.
• W2045292004 sameAs 2045292004 @default.
• W2045292004 citedByCount "48" @default.
• W2045292004 countsByYear W20452920042014 @default.
• W2045292004 countsByYear W20452920042018 @default.
• W2045292004 countsByYear W20452920042022 @default.
• W2045292004 crossrefType "journal-article" @default.
• W2045292004 hasAuthorship W2045292004A5002737792 @default.
• W2045292004 hasAuthorship W2045292004A5025147400 @default.
• W2045292004 hasAuthorship W2045292004A5046668269 @default.
• W2045292004 hasAuthorship W2045292004A5054759359 @default.
• W2045292004 hasAuthorship W2045292004A5063389942 @default.
• W2045292004 hasAuthorship W2045292004A5064171627 @default.
• W2045292004 hasAuthorship W2045292004A5069116689 @default.
• W2045292004 hasAuthorship W2045292004A5074455927 @default.
• W2045292004 hasConcept C10515644 @default.
• W2045292004 hasConcept C121608353 @default.
• W2045292004 hasConcept C126322002 @default.
• W2045292004 hasConcept C126894567 @default.
• W2045292004 hasConcept C142724271 @default.
• W2045292004 hasConcept C143998085 @default.
• W2045292004 hasConcept C144301174 @default.
• W2045292004 hasConcept C146357865 @default.
• W2045292004 hasConcept C151730666 @default.
• W2045292004 hasConcept C204232928 @default.
• W2045292004 hasConcept C2775910329 @default.
• W2045292004 hasConcept C2778065480 @default.
• W2045292004 hasConcept C2780091936 @default.
• W2045292004 hasConcept C2780352672 @default.
• W2045292004 hasConcept C38180746 @default.
• W2045292004 hasConcept C4224716 @default.
• W2045292004 hasConcept C50382708 @default.
• W2045292004 hasConcept C509974204 @default.
• W2045292004 hasConcept C71924100 @default.
• W2045292004 hasConcept C86803240 @default.
• W2045292004 hasConceptScore W2045292004C10515644 @default.
• W2045292004 hasConceptScore W2045292004C121608353 @default.
• W2045292004 hasConceptScore W2045292004C126322002 @default.
• W2045292004 hasConceptScore W2045292004C126894567 @default.
• W2045292004 hasConceptScore W2045292004C142724271 @default.
• W2045292004 hasConceptScore W2045292004C143998085 @default.
• W2045292004 hasConceptScore W2045292004C144301174 @default.
• W2045292004 hasConceptScore W2045292004C146357865 @default.
• W2045292004 hasConceptScore W2045292004C151730666 @default.
• W2045292004 hasConceptScore W2045292004C204232928 @default.
• W2045292004 hasConceptScore W2045292004C2775910329 @default.
• W2045292004 hasConceptScore W2045292004C2778065480 @default.
• W2045292004 hasConceptScore W2045292004C2780091936 @default.
• W2045292004 hasConceptScore W2045292004C2780352672 @default.
• W2045292004 hasConceptScore W2045292004C38180746 @default.
• W2045292004 hasConceptScore W2045292004C4224716 @default.
• W2045292004 hasConceptScore W2045292004C50382708 @default.
• W2045292004 hasConceptScore W2045292004C509974204 @default.
• W2045292004 hasConceptScore W2045292004C71924100 @default.
• W2045292004 hasConceptScore W2045292004C86803240 @default.
• W2045292004 hasIssue "3" @default.
• W2045292004 hasLocation W20452920041 @default.
• W2045292004 hasLocation W20452920042 @default.
• W2045292004 hasOpenAccess W2045292004 @default.
• W2045292004 hasPrimaryLocation W20452920041 @default.
• W2045292004 hasRelatedWork W2122875447 @default.
• W2045292004 hasRelatedWork W2144587411 @default.
• W2045292004 hasRelatedWork W2413683736 @default.
• W2045292004 hasRelatedWork W2595618663 @default.
• W2045292004 hasRelatedWork W2910048357 @default.

• next