FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045294448> ?p ?o ?g. }

• W2045294448 endingPage "1678" @default.
• W2045294448 startingPage "1669" @default.
• W2045294448 abstract "The pre-T cell receptor α (pTα) protein is a critical component of the pre-T cell receptor complex in early thymocytes. The expression of the pTα gene is one of the earliest markers of the T cell lineage and occurs exclusively in pre-T cells. To investigate the molecular basis of thymocyte-specific gene expression, we searched for the genomic elements regulating transcription of the mouse pTα gene. We now report that expression of the pTα gene is primarily controlled by an upstream genomic region, which can drive thymocyte-specific expression of a marker gene in transgenic mice. Within this region, we have identified two specific DNase-hypersensitive sites corresponding to a proximal promoter and an upstream transcriptional enhancer. The pTα enhancer appears to function preferentially in pre-T cell lines and binds multiple nuclear factors, including YY1. The enhancer also contains two G-rich stretches homologous to a critical region of the thymocyte-specific lck proximal promoter. Here we show that these sites bind a common nuclear factor and identify it as the zinc finger protein ZBP-89. Our data establish a novel experimental model for thymocyte-specific gene expression and suggest an important role for ZBP-89 in T cell development." @default.
• W2045294448 created "2016-06-24" @default.
• W2045294448 creator A5004192129 @default.
• W2045294448 creator A5070752173 @default.
• W2045294448 date "1999-05-17" @default.
• W2045294448 modified "2023-10-11" @default.
• W2045294448 title "Expression of the Mouse Pre-T Cell Receptor α Gene Is Controlled by an Upstream Region Containing a Transcriptional Enhancer" @default.
• W2045294448 cites W1484859051 @default.
• W2045294448 cites W1496007960 @default.
• W2045294448 cites W1547758273 @default.
• W2045294448 cites W1744228743 @default.
• W2045294448 cites W1968115774 @default.
• W2045294448 cites W1969213218 @default.
• W2045294448 cites W1969770714 @default.
• W2045294448 cites W1976852696 @default.
• W2045294448 cites W1979257953 @default.
• W2045294448 cites W1982295124 @default.
• W2045294448 cites W1983320210 @default.
• W2045294448 cites W1997759424 @default.
• W2045294448 cites W1998931004 @default.
• W2045294448 cites W2012985555 @default.
• W2045294448 cites W2032019900 @default.
• W2045294448 cites W2036455976 @default.
• W2045294448 cites W2044735117 @default.
• W2045294448 cites W2050198431 @default.
• W2045294448 cites W2067101123 @default.
• W2045294448 cites W2071632799 @default.
• W2045294448 cites W2080809922 @default.
• W2045294448 cites W2087203311 @default.
• W2045294448 cites W2088713375 @default.
• W2045294448 cites W2090344918 @default.
• W2045294448 cites W2092680301 @default.
• W2045294448 cites W2106777595 @default.
• W2045294448 cites W2118446959 @default.
• W2045294448 cites W2123327796 @default.
• W2045294448 cites W2128110073 @default.
• W2045294448 cites W2142026128 @default.
• W2045294448 cites W2143041969 @default.
• W2045294448 cites W2143752402 @default.
• W2045294448 cites W2149401540 @default.
• W2045294448 cites W2164488073 @default.
• W2045294448 cites W2169923455 @default.
• W2045294448 cites W2173817007 @default.
• W2045294448 cites W2413859809 @default.
• W2045294448 cites W250451609 @default.
• W2045294448 cites W4313333732 @default.
• W2045294448 cites W4313341351 @default.
• W2045294448 cites W88875626 @default.
• W2045294448 doi "https://doi.org/10.1084/jem.189.10.1669" @default.
• W2045294448 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193641" @default.
• W2045294448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10330446" @default.
• W2045294448 hasPublicationYear "1999" @default.
• W2045294448 type Work @default.
• W2045294448 sameAs 2045294448 @default.
• W2045294448 citedByCount "53" @default.
• W2045294448 countsByYear W20452944482013 @default.
• W2045294448 countsByYear W20452944482016 @default.
• W2045294448 countsByYear W20452944482019 @default.
• W2045294448 countsByYear W20452944482020 @default.
• W2045294448 crossrefType "journal-article" @default.
• W2045294448 hasAuthorship W2045294448A5004192129 @default.
• W2045294448 hasAuthorship W2045294448A5070752173 @default.
• W2045294448 hasBestOaLocation W20452944481 @default.
• W2045294448 hasConcept C101762097 @default.
• W2045294448 hasConcept C104317684 @default.
• W2045294448 hasConcept C111936080 @default.
• W2045294448 hasConcept C150194340 @default.
• W2045294448 hasConcept C153911025 @default.
• W2045294448 hasConcept C165864922 @default.
• W2045294448 hasConcept C21784809 @default.
• W2045294448 hasConcept C24284526 @default.
• W2045294448 hasConcept C27153228 @default.
• W2045294448 hasConcept C2776090121 @default.
• W2045294448 hasConcept C2778954852 @default.
• W2045294448 hasConcept C54355233 @default.
• W2045294448 hasConcept C58237431 @default.
• W2045294448 hasConcept C62944979 @default.
• W2045294448 hasConcept C86339819 @default.
• W2045294448 hasConcept C86803240 @default.
• W2045294448 hasConcept C8891405 @default.
• W2045294448 hasConceptScore W2045294448C101762097 @default.
• W2045294448 hasConceptScore W2045294448C104317684 @default.
• W2045294448 hasConceptScore W2045294448C111936080 @default.
• W2045294448 hasConceptScore W2045294448C150194340 @default.
• W2045294448 hasConceptScore W2045294448C153911025 @default.
• W2045294448 hasConceptScore W2045294448C165864922 @default.
• W2045294448 hasConceptScore W2045294448C21784809 @default.
• W2045294448 hasConceptScore W2045294448C24284526 @default.
• W2045294448 hasConceptScore W2045294448C27153228 @default.
• W2045294448 hasConceptScore W2045294448C2776090121 @default.
• W2045294448 hasConceptScore W2045294448C2778954852 @default.
• W2045294448 hasConceptScore W2045294448C54355233 @default.
• W2045294448 hasConceptScore W2045294448C58237431 @default.
• W2045294448 hasConceptScore W2045294448C62944979 @default.
• W2045294448 hasConceptScore W2045294448C86339819 @default.
• W2045294448 hasConceptScore W2045294448C86803240 @default.
• W2045294448 hasConceptScore W2045294448C8891405 @default.
• W2045294448 hasIssue "10" @default.

• next