Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045295079> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2045295079 endingPage "228" @default.
- W2045295079 startingPage "216" @default.
- W2045295079 abstract "The effect of phenobarbital on thyroid function and the metabolism and biliary excretion of thyroxine in rats was determined. Phenobarbital, administered for 2 weeks at a dose of 100 mg/kg/day, resulted in an increase in hepatic and thyroid gland weights, decreased circulating levels of T4, T3 and rT3, and increased TSH levels in male and female rats. After 3 months of treatment liver and thyroid weights were still increased; however, hormone values were not as markedly affected indicating that the rats had partially compensated for the effect on thyroid function. In thyroidectomized rats the plasma clearance of thyroxine was increased with phenobarbital. In bile duct cannulated phenobarbital-treated male rats the hepatic uptake at 4 hr was markedly increased. Bile flow was increased and the 4-hr cumulative biliary excretion of administered radioactivity was increased by 42%. Most of the increase in the excretion (76%) was accounted for by an increase in the excretion of thyroxine-glucuronide in phenobarbital-treated rats. Hepatic thyroxine-glucuronyltransferase activity in phenobarbital-treated rats expressed as picomoles per milligram of protein was increased by 40%; enzyme activity per gram of liver was increased by about twofold which, coupled with increased hepatic weight, resulted in about a threefold increase in total hepatic thyroxine-glucuronyltransferase activity in phenobarbital-treated rats as compared to that of controls. Qualitatively similar effects on metabolism, excretion, and enzyme induction were noted in female rats; however, the magnitude of increase was less than that observed in male rats. It is concluded that the effect of phenobarbital on thyroid function in rats is primarily a result of its effects on the hepatic disposition of thyroid hormone. The induction of thyroxine-glucuronyltransferase appears to play an important role in the increased metabolism and excretion of thyroxine in phenobarbital-treated rats." @default.
- W2045295079 created "2016-06-24" @default.
- W2045295079 creator A5033969852 @default.
- W2045295079 creator A5056892571 @default.
- W2045295079 creator A5071223484 @default.
- W2045295079 creator A5087511546 @default.
- W2045295079 date "1989-06-01" @default.
- W2045295079 modified "2023-10-12" @default.
- W2045295079 title "The effect of phenobarbital on the metabolism and excretion of thyroxine in rats" @default.
- W2045295079 cites W1495782386 @default.
- W2045295079 cites W1968216865 @default.
- W2045295079 cites W1971342293 @default.
- W2045295079 cites W1995611176 @default.
- W2045295079 cites W2007027642 @default.
- W2045295079 cites W2007734870 @default.
- W2045295079 cites W2012482676 @default.
- W2045295079 cites W2038892159 @default.
- W2045295079 cites W2054942726 @default.
- W2045295079 cites W2066260934 @default.
- W2045295079 cites W2068681503 @default.
- W2045295079 cites W2069809363 @default.
- W2045295079 cites W2074551829 @default.
- W2045295079 cites W2077608581 @default.
- W2045295079 cites W2083339846 @default.
- W2045295079 cites W2087088089 @default.
- W2045295079 cites W2129364261 @default.
- W2045295079 cites W2396220883 @default.
- W2045295079 cites W2413573154 @default.
- W2045295079 doi "https://doi.org/10.1016/0041-008x(89)90004-5" @default.
- W2045295079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2734788" @default.
- W2045295079 hasPublicationYear "1989" @default.
- W2045295079 type Work @default.
- W2045295079 sameAs 2045295079 @default.
- W2045295079 citedByCount "177" @default.
- W2045295079 countsByYear W20452950792012 @default.
- W2045295079 countsByYear W20452950792013 @default.
- W2045295079 countsByYear W20452950792015 @default.
- W2045295079 countsByYear W20452950792018 @default.
- W2045295079 countsByYear W20452950792019 @default.
- W2045295079 countsByYear W20452950792020 @default.
- W2045295079 countsByYear W20452950792021 @default.
- W2045295079 countsByYear W20452950792022 @default.
- W2045295079 countsByYear W20452950792023 @default.
- W2045295079 crossrefType "journal-article" @default.
- W2045295079 hasAuthorship W2045295079A5033969852 @default.
- W2045295079 hasAuthorship W2045295079A5056892571 @default.
- W2045295079 hasAuthorship W2045295079A5071223484 @default.
- W2045295079 hasAuthorship W2045295079A5087511546 @default.
- W2045295079 hasConcept C10146269 @default.
- W2045295079 hasConcept C126322002 @default.
- W2045295079 hasConcept C132154277 @default.
- W2045295079 hasConcept C134018914 @default.
- W2045295079 hasConcept C181199279 @default.
- W2045295079 hasConcept C185592680 @default.
- W2045295079 hasConcept C2778793413 @default.
- W2045295079 hasConcept C526584372 @default.
- W2045295079 hasConcept C55493867 @default.
- W2045295079 hasConcept C62231903 @default.
- W2045295079 hasConcept C71924100 @default.
- W2045295079 hasConcept C86803240 @default.
- W2045295079 hasConceptScore W2045295079C10146269 @default.
- W2045295079 hasConceptScore W2045295079C126322002 @default.
- W2045295079 hasConceptScore W2045295079C132154277 @default.
- W2045295079 hasConceptScore W2045295079C134018914 @default.
- W2045295079 hasConceptScore W2045295079C181199279 @default.
- W2045295079 hasConceptScore W2045295079C185592680 @default.
- W2045295079 hasConceptScore W2045295079C2778793413 @default.
- W2045295079 hasConceptScore W2045295079C526584372 @default.
- W2045295079 hasConceptScore W2045295079C55493867 @default.
- W2045295079 hasConceptScore W2045295079C62231903 @default.
- W2045295079 hasConceptScore W2045295079C71924100 @default.
- W2045295079 hasConceptScore W2045295079C86803240 @default.
- W2045295079 hasIssue "2" @default.
- W2045295079 hasLocation W20452950791 @default.
- W2045295079 hasLocation W20452950792 @default.
- W2045295079 hasOpenAccess W2045295079 @default.
- W2045295079 hasPrimaryLocation W20452950791 @default.
- W2045295079 hasRelatedWork W151673537 @default.
- W2045295079 hasRelatedWork W1965186264 @default.
- W2045295079 hasRelatedWork W2004166006 @default.
- W2045295079 hasRelatedWork W2053549685 @default.
- W2045295079 hasRelatedWork W2092290234 @default.
- W2045295079 hasRelatedWork W2206343495 @default.
- W2045295079 hasRelatedWork W2266773093 @default.
- W2045295079 hasRelatedWork W2398542069 @default.
- W2045295079 hasRelatedWork W2422775895 @default.
- W2045295079 hasRelatedWork W2460701630 @default.
- W2045295079 hasVolume "99" @default.
- W2045295079 isParatext "false" @default.
- W2045295079 isRetracted "false" @default.
- W2045295079 magId "2045295079" @default.
- W2045295079 workType "article" @default.