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- W2045295256 abstract "Sugars and sugar degradation products readily react in vitro with guanine derivatives, resulting in the formation of DNA-bound advanced glycation end-products (DNA-AGEs). The two diastereomers of N(2)-(1-carboxyethyl)-2'-deoxyguanosine (CEdG(A,B)) and the cyclic adduct of methylglyoxal and 2'-deoxyguanosine (mdG) (N(2)-7-bis(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine have also been detected in cultured cells and/or in vivo. LC-MS/MS methods have been developed to analyze sensitively DNA adducts in vitro and in vivo. In this paper, the chemical structures of possible DNA-AGEs and the application of LC-MS/MS to measure DNA-AGEs are reviewed." @default.
- W2045295256 created "2016-06-24" @default.
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- W2045295256 date "2007-08-01" @default.
- W2045295256 modified "2023-09-24" @default.
- W2045295256 title "Analysis of DNA-bound advanced glycation end-products by LC and mass spectrometry" @default.
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- W2045295256 doi "https://doi.org/10.1016/j.jchromb.2006.11.033" @default.
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