Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045296190> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W2045296190 endingPage "225" @default.
- W2045296190 startingPage "225" @default.
- W2045296190 abstract "Molecular biology has been applied to the development of hemoglobin-based oxygen carrier (HBOC) proteins that can be expressed in bacteria or yeast. The transformation of the hemoglobin molecule into an HBOC requires a variety of modifications for rendering the acellular molecule of hemoglobin physiologically acceptable when transfused in circulation. Hemoglobins with different oxygen affinities can be obtained by introducing mutations at the heme pocket, the site of oxygen binding, or by introducing surface mutations that stabilize the hemoglobin molecule in the low-oxygen-affinity state. Modification of the size of the heme pocket is also used to hinder nitric oxide depletion and associated vasoconstriction. Introduction of cysteine residues on the hemoglobin surface allows formation of intermolecular bonds and formation of polymeric HBOCs. These polymers of recombinant hemoglobin have the characteristics of molecular size, molecular stability, and oxygen delivery to hypoxic tissue suitable for an HBOC." @default.
- W2045296190 created "2016-06-24" @default.
- W2045296190 creator A5025160744 @default.
- W2045296190 creator A5027518220 @default.
- W2045296190 date "2000-04-01" @default.
- W2045296190 modified "2023-09-25" @default.
- W2045296190 title "Reduction of interference from a blood substitute using new reagents from Roche Diagnostics for the Hitachi analyzer line" @default.
- W2045296190 doi "https://doi.org/10.1016/s0009-9120(00)00086-2" @default.
- W2045296190 hasPublicationYear "2000" @default.
- W2045296190 type Work @default.
- W2045296190 sameAs 2045296190 @default.
- W2045296190 citedByCount "0" @default.
- W2045296190 crossrefType "journal-article" @default.
- W2045296190 hasAuthorship W2045296190A5025160744 @default.
- W2045296190 hasAuthorship W2045296190A5027518220 @default.
- W2045296190 hasConcept C178790620 @default.
- W2045296190 hasConcept C181199279 @default.
- W2045296190 hasConcept C185592680 @default.
- W2045296190 hasConcept C2776217839 @default.
- W2045296190 hasConcept C2778917026 @default.
- W2045296190 hasConcept C519581460 @default.
- W2045296190 hasConcept C540031477 @default.
- W2045296190 hasConcept C55493867 @default.
- W2045296190 hasConceptScore W2045296190C178790620 @default.
- W2045296190 hasConceptScore W2045296190C181199279 @default.
- W2045296190 hasConceptScore W2045296190C185592680 @default.
- W2045296190 hasConceptScore W2045296190C2776217839 @default.
- W2045296190 hasConceptScore W2045296190C2778917026 @default.
- W2045296190 hasConceptScore W2045296190C519581460 @default.
- W2045296190 hasConceptScore W2045296190C540031477 @default.
- W2045296190 hasConceptScore W2045296190C55493867 @default.
- W2045296190 hasIssue "3" @default.
- W2045296190 hasLocation W20452961901 @default.
- W2045296190 hasOpenAccess W2045296190 @default.
- W2045296190 hasPrimaryLocation W20452961901 @default.
- W2045296190 hasRelatedWork W2012706913 @default.
- W2045296190 hasRelatedWork W2017402165 @default.
- W2045296190 hasRelatedWork W2022768087 @default.
- W2045296190 hasRelatedWork W2048403134 @default.
- W2045296190 hasRelatedWork W2375999138 @default.
- W2045296190 hasRelatedWork W2413323627 @default.
- W2045296190 hasRelatedWork W2415752239 @default.
- W2045296190 hasRelatedWork W2902892814 @default.
- W2045296190 hasRelatedWork W3181904496 @default.
- W2045296190 hasRelatedWork W2078440854 @default.
- W2045296190 hasVolume "33" @default.
- W2045296190 isParatext "false" @default.
- W2045296190 isRetracted "false" @default.
- W2045296190 magId "2045296190" @default.
- W2045296190 workType "article" @default.