FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045301605> ?p ?o ?g. }

• W2045301605 abstract "It has been suggested that the neonatal Fc receptor (FcRn) is a primary determinant of the distribution of IgG to the brain. In the present report, (125)I-labeled 7E3, a monoclonal IgG1 antibody, was injected intravenously to groups of FcRn-deficient mice and C57BL/6J control mice. Sub-groups of three mice were sacrificed at several time points. Blood and brain tissue were harvested and radioactivity was assessed. Antibody concentrations in brain were corrected for residual blood using (51)Cr-labeled red blood cells. Data were analyzed via WinNonlin, and areas under plasma and tissue concentration vs. time curves (AUCs) were assessed via the Bailer method. The apparent plasma elimination half-life and clearance of 7E3 were 13.61 +/- 0.61 days and 6.5 +/- 0.10 ml/day/kg in control mice and 0.70 +/- 0.05 days and 63.5 +/- 2.7 ml/day/kg in the knockout mice. Plasma and brain AUCs (0-10 days) were found to be 3,338.7 +/- 50.4 and 7.46 +/- 0.5 nM day in control animals and 781.2 +/- 16.6 and 1.65 +/- 0.1 nM day in FcRn-deficient animals. There was no significant difference between brain-to-plasma AUC ratios in control and FcRn-deficient mice (0.0022 +/- 0.00015 vs. 0.0021 +/- 0.00011, p = 0.3347). Two-way analysis of variance showed no significant differences, at any time point, between brain-to-plasma concentration ratios determined from control and knockout animals. The results suggest that FcRn does not contribute significantly to the blood-brain barrier for IgG in mice, and the data suggest that FcRn is not responsible for the low exposure of IgG in the brain relative to plasma." @default.
• W2045301605 created "2016-06-24" @default.
• W2045301605 creator A5006940157 @default.
• W2045301605 creator A5029610349 @default.
• W2045301605 date "2009-07-28" @default.
• W2045301605 modified "2023-10-10" @default.
• W2045301605 title "Investigation of the Influence of FcRn on the Distribution of IgG to the Brain" @default.
• W2045301605 cites W1484884286 @default.
• W2045301605 cites W1505676752 @default.
• W2045301605 cites W1547237200 @default.
• W2045301605 cites W1686249017 @default.
• W2045301605 cites W1926541123 @default.
• W2045301605 cites W1951663525 @default.
• W2045301605 cites W1972894937 @default.
• W2045301605 cites W1979264461 @default.
• W2045301605 cites W1989206786 @default.
• W2045301605 cites W2002765161 @default.
• W2045301605 cites W2006962652 @default.
• W2045301605 cites W2012967644 @default.
• W2045301605 cites W2021759214 @default.
• W2045301605 cites W2025012298 @default.
• W2045301605 cites W2029789274 @default.
• W2045301605 cites W2048954270 @default.
• W2045301605 cites W2051774696 @default.
• W2045301605 cites W2057915227 @default.
• W2045301605 cites W2058344808 @default.
• W2045301605 cites W2069978926 @default.
• W2045301605 cites W2075689961 @default.
• W2045301605 cites W2084824298 @default.
• W2045301605 cites W2088930369 @default.
• W2045301605 cites W2096555843 @default.
• W2045301605 cites W2111462418 @default.
• W2045301605 cites W2112001901 @default.
• W2045301605 cites W2113413385 @default.
• W2045301605 cites W2114949839 @default.
• W2045301605 cites W2120599736 @default.
• W2045301605 cites W2138771248 @default.
• W2045301605 cites W2142709610 @default.
• W2045301605 cites W2162907283 @default.
• W2045301605 cites W2168399625 @default.
• W2045301605 cites W2171811002 @default.
• W2045301605 cites W4234565556 @default.
• W2045301605 cites W99970865 @default.
• W2045301605 doi "https://doi.org/10.1208/s12248-009-9129-9" @default.
• W2045301605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2758122" @default.
• W2045301605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19636712" @default.
• W2045301605 hasPublicationYear "2009" @default.
• W2045301605 type Work @default.
• W2045301605 sameAs 2045301605 @default.
• W2045301605 citedByCount "83" @default.
• W2045301605 countsByYear W20453016052012 @default.
• W2045301605 countsByYear W20453016052013 @default.
• W2045301605 countsByYear W20453016052014 @default.
• W2045301605 countsByYear W20453016052015 @default.
• W2045301605 countsByYear W20453016052016 @default.
• W2045301605 countsByYear W20453016052017 @default.
• W2045301605 countsByYear W20453016052018 @default.
• W2045301605 countsByYear W20453016052019 @default.
• W2045301605 countsByYear W20453016052020 @default.
• W2045301605 countsByYear W20453016052021 @default.
• W2045301605 countsByYear W20453016052022 @default.
• W2045301605 countsByYear W20453016052023 @default.
• W2045301605 crossrefType "journal-article" @default.
• W2045301605 hasAuthorship W2045301605A5006940157 @default.
• W2045301605 hasAuthorship W2045301605A5029610349 @default.
• W2045301605 hasBestOaLocation W20453016052 @default.
• W2045301605 hasConcept C110121322 @default.
• W2045301605 hasConcept C112705442 @default.
• W2045301605 hasConcept C126322002 @default.
• W2045301605 hasConcept C134018914 @default.
• W2045301605 hasConcept C134306372 @default.
• W2045301605 hasConcept C150903083 @default.
• W2045301605 hasConcept C159654299 @default.
• W2045301605 hasConcept C170493617 @default.
• W2045301605 hasConcept C182704531 @default.
• W2045301605 hasConcept C185592680 @default.
• W2045301605 hasConcept C203014093 @default.
• W2045301605 hasConcept C207001950 @default.
• W2045301605 hasConcept C33923547 @default.
• W2045301605 hasConcept C542903549 @default.
• W2045301605 hasConcept C71924100 @default.
• W2045301605 hasConcept C86803240 @default.
• W2045301605 hasConcept C98274493 @default.
• W2045301605 hasConceptScore W2045301605C110121322 @default.
• W2045301605 hasConceptScore W2045301605C112705442 @default.
• W2045301605 hasConceptScore W2045301605C126322002 @default.
• W2045301605 hasConceptScore W2045301605C134018914 @default.
• W2045301605 hasConceptScore W2045301605C134306372 @default.
• W2045301605 hasConceptScore W2045301605C150903083 @default.
• W2045301605 hasConceptScore W2045301605C159654299 @default.
• W2045301605 hasConceptScore W2045301605C170493617 @default.
• W2045301605 hasConceptScore W2045301605C182704531 @default.
• W2045301605 hasConceptScore W2045301605C185592680 @default.
• W2045301605 hasConceptScore W2045301605C203014093 @default.
• W2045301605 hasConceptScore W2045301605C207001950 @default.
• W2045301605 hasConceptScore W2045301605C33923547 @default.
• W2045301605 hasConceptScore W2045301605C542903549 @default.
• W2045301605 hasConceptScore W2045301605C71924100 @default.
• W2045301605 hasConceptScore W2045301605C86803240 @default.
• W2045301605 hasConceptScore W2045301605C98274493 @default.

• next