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- W2045302001 abstract "Activated microglia by neuronal injury or inflammatory stimulation overproduce nitric oxide (NO) by inducible nitric oxide synthase (iNOS) and reactive oxygen species (ROS) such as superoxide anion, resulting in neurodegenerative diseases. The toxic peroxynitrite (ONOO−), the reaction product of NO and superoxide anion further contributes to oxidative neurotoxicity. A butanol fraction obtained from 50% ethanol extracts of Opuntia ficus indica var. saboten (Cactaceae) stem (SK OFB901) and its hydrolysis product (SK OFB901H) inhibited the production of NO in LPS-activated microglia in a dose dependent manner (IC50 15.9, 4.2 µg/mL, respectively). They also suppressed the expression of protein and mRNA of iNOS in LPS-activated microglial cells at higher than 30 µg/mL as observed by western blot analysis and RT-PCR experiment. They also inhibited the degradation of I-κB-α in activated microglia. Moreover, they showed strong activity of peroxynitrite scavenging in a cell free bioassay system. These results imply that Opuntia ficus indica may have neuroprotective activity through the inhibition of NO production by activated microglial cells and peroxynitrite scavenging activity. Copyright © 2006 John Wiley & Sons, Ltd." @default.
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- W2045302001 date "2006-01-01" @default.
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- W2045302001 title "Inhibition of nitric oxide synthase expression in activated microglia and peroxynitrite scavenging activity byOpuntia ficus indica var.saboten" @default.
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- W2045302001 doi "https://doi.org/10.1002/ptr.1942" @default.
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