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- W2045303011 abstract "Abstract Fruit and vegetable consumption has been heralded for its ability to decrease the overall risk of developing cancer and other diseases. Mounting evidence supports the beneficial nature of antioxidants, carotenoids, and other phytonutrients found in fruits and vegetables. One proposed mechanism of antioxidant protection is the shielding of cellular DNA from oxidative damage and therefore mutations. This may be especially helpful in older populations. We tested the concept that a daily regimen of supplementation with fruit and vegetable extracts (JuicePlus™) would reduce the amount of DNA damage in the peripheral lymphocytes of the elderly. In a blind study, a group of twenty elderly volunteers (mean age=68) were given supplements twice daily for 80 days with blood samples drawn before and after intervention. These samples were compared using the comet assay, a technique that quantifies DNA damage to individual nuclei. Each sample was tested in triplicate, and tail moment data was collected from over 200 comets per sample. Paired t-test analysis revealed a highly significant (p" @default.
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- W2045303011 date "1999-10-01" @default.
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- W2045303011 title "Supplementation with fruit and vegetable extracts may decrease DNA damage in the peripheral lymphocytes of an elderly population" @default.
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- W2045303011 doi "https://doi.org/10.1016/s0271-5317(99)00107-4" @default.
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