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- W2045304841 abstract "The clinical and serologic features of patients with systemic lupus erythematosus (SLE) vary enormously, and for this reason it has been difficult to develop a unifyi ng concept of this dis ease. This has led to the practice of identifying subsets of SLE by grouping patients with similar clinical and/or laboratory features, thus defining more homogeneous groups of patients with a pre dictable course or response to treatment. SLE sub sets have been defined by constellations of clinical features, similar laboratory abnormalities, similar pathologic changes, or combinations of these. In a recent issue of the JOURNAL, Provost and Reichlin I reviewed their findings in a subset of LE patients who are antinuclear antibody (ANA) negative but who have circulating antibodies to the cytoplasmic antigens Ro and La. Serologic subsetting has been a popular exercise during the past 10 to 15 years (Table I)' Schur and Sandson! were the first to emphasize that low serum complement levels and high levels of anti deoxyribonucleic (DNA) antibodies are present in patients with active SLE. High concentrations of antibodies to DNA, especially complement-fixing anti-DNA antibodies, identify an SLE subset with an increased risk for renal disease. In 1969 Clark, Reichlin, and Tomasi identified an antibody in lupus sera which reacted with a soluble cytoplas mic antigen (Ro). Such antibodies were found in approximately 30% of patients with SLE and in a much higher proportion of those with Sjogren's syndrome. This antibody has recently been shown to form a line of identity in immunodiffusion with" @default.
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- W2045304841 date "1981-04-01" @default.
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- W2045304841 title "Distinctive cutaneous subsets in the spectrum of lupus erythematosus" @default.
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- W2045304841 doi "https://doi.org/10.1016/s0190-9622(81)80261-7" @default.
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