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- W2045305092 abstract "Invariant natural killer T (iNKT) cells have adjuvant activity due to their ability to produce large amounts of IFN-gamma, which activates other cells in innate and acquired systems, and orchestrates protective immunity. Based on these adjuvant mechanisms, we developed iNKT cell-targeted adjuvant therapy and carried out a phase I/IIa trial on advanced lung cancer patients. The patient group with increased numbers of IFN-gamma-producing cells showed prolonged survival with a median survival time of 31.9 months. Sixty percent of the patients in this group survived for more than 2 years with only a primary treatment and without tumor progression and metastasis." @default.
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- W2045305092 date "2010-04-01" @default.
- W2045305092 modified "2023-09-23" @default.
- W2045305092 title "Adjuvant activity mediated by iNKT cells" @default.
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- W2045305092 doi "https://doi.org/10.1016/j.smim.2009.10.002" @default.
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