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- W2045309144 endingPage "1811" @default.
- W2045309144 startingPage "1799" @default.
- W2045309144 abstract "Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system (CNS). A body of research over recent years has demonstrated a key role for mitogen-activated protein kinase (MAPK) pathway signaling in the development and behavior of PAs. Several mechanisms lead to activation of this pathway in PA, mostly in a mutually exclusive manner, with constitutive BRAF kinase activation subsequent to gene fusion being the most frequent. The high specificity of this fusion to PA when compared with other CNS tumors has diagnostic utility. In addition, the frequency of alteration of this key pathway provides an opportunity for molecularly targeted therapy in this tumor. Here, we review the current knowledge on mechanisms of MAPK activation in PA and some of the downstream consequences of this activation, which are now starting to be elucidated both in vitro and in vivo, as well as clinical considerations and possible future directions." @default.
- W2045309144 created "2016-06-24" @default.
- W2045309144 creator A5010582324 @default.
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- W2045309144 creator A5020409208 @default.
- W2045309144 creator A5041096535 @default.
- W2045309144 creator A5064456190 @default.
- W2045309144 date "2011-12-13" @default.
- W2045309144 modified "2023-10-12" @default.
- W2045309144 title "MAPK pathway activation in pilocytic astrocytoma" @default.
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