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- W2045311369 abstract "MSSP gene-2 encodes at least three alternative splicing products, MSSP-1, MSSP-2, and Scr2, which have been implied to function as factors regulating DNA replication, transcription, apoptosis induction, and cell-cycle movement, via the interaction with C-MYC. We have previously shown that the Mup1 sequence from -474 to -440 in the region required for transactivation of the MSSP gene-2 was protected from DNaseI digestion in vitro. Here, we report that the Mup1 sequence carries a positive transcriptional activity, and that the activity was lost by point mutations that inhibited the formation of specific nucleoprotein complexes on the sequence. In Southwestern analyses, two proteins of 38 and 62kDa directly interacted with the Mup1 sequence." @default.
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- W2045311369 date "1998-07-01" @default.
- W2045311369 modified "2023-10-17" @default.
- W2045311369 title "Characterization of an element positively regulating the transcription of MSSP gene-2 which encodes C-MYC binding proteins" @default.
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- W2045311369 doi "https://doi.org/10.1016/s0378-1119(98)00263-7" @default.
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