Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045311928> ?p ?o ?g. }
- W2045311928 endingPage "2093" @default.
- W2045311928 startingPage "2080" @default.
- W2045311928 abstract "ADAM17 has been initially identified as the main sheddase responsible for releasing the soluble form of a variety of cell-surface proteins, including growth factors, cytokines, cell adhesion molecules, and receptors, most of which are associated with pathological processes, including cancer and inflammation. However, the function and composition of the ADAM17-dependent secretome on a proteome-wide scale is poorly understood. In this study, we observed that the ADAM17-dependent secretome plays an important role in promoting cell proliferation and migration. To further demonstrate the repertoire of proteins involved in this cross-talk, we employed mass-spectrometry-based proteomics using nonmetabolic and metabolic labeling approaches to explore the secretome composition of wild-type and ADAM17(-/-) knockout mouse embryonic fibroblast (mEF) cells. Bioinformatic analyses indicated the differential regulation of 277 soluble proteins in the ADAM17-dependent secretome as well as novel direct ADAM17 cleavage substrates, such as mimecan and perlecan. Furthermore, we found that the ADAM17-dependent secretome promoted an opposite regulation of ERK and FAK pathways as well as PPARγ downstream activation. These findings demonstrated fine-tuning of cell signaling rendered by the soluble molecules mediated by ADAM17." @default.
- W2045311928 created "2016-06-24" @default.
- W2045311928 creator A5003157951 @default.
- W2045311928 creator A5013511941 @default.
- W2045311928 creator A5016609995 @default.
- W2045311928 creator A5019100368 @default.
- W2045311928 creator A5022619260 @default.
- W2045311928 creator A5059222256 @default.
- W2045311928 creator A5063422755 @default.
- W2045311928 creator A5069505711 @default.
- W2045311928 date "2014-03-13" @default.
- W2045311928 modified "2023-10-14" @default.
- W2045311928 title "Deciphering the Role of the ADAM17-Dependent Secretome in Cell Signaling" @default.
- W2045311928 cites W1498096612 @default.
- W2045311928 cites W1869320174 @default.
- W2045311928 cites W1963691526 @default.
- W2045311928 cites W1968558772 @default.
- W2045311928 cites W1970458434 @default.
- W2045311928 cites W1971747634 @default.
- W2045311928 cites W1972196680 @default.
- W2045311928 cites W1974666338 @default.
- W2045311928 cites W1981827621 @default.
- W2045311928 cites W1986577090 @default.
- W2045311928 cites W1988576610 @default.
- W2045311928 cites W1988973424 @default.
- W2045311928 cites W1992301100 @default.
- W2045311928 cites W1992557354 @default.
- W2045311928 cites W1992660677 @default.
- W2045311928 cites W1994924350 @default.
- W2045311928 cites W2000526152 @default.
- W2045311928 cites W2000919336 @default.
- W2045311928 cites W2003630221 @default.
- W2045311928 cites W2003850699 @default.
- W2045311928 cites W2004611201 @default.
- W2045311928 cites W2005334224 @default.
- W2045311928 cites W2019409994 @default.
- W2045311928 cites W2019698756 @default.
- W2045311928 cites W2019771217 @default.
- W2045311928 cites W2027238998 @default.
- W2045311928 cites W2027526894 @default.
- W2045311928 cites W2033848780 @default.
- W2045311928 cites W2036321220 @default.
- W2045311928 cites W2044312475 @default.
- W2045311928 cites W2047121898 @default.
- W2045311928 cites W2047427057 @default.
- W2045311928 cites W2048164934 @default.
- W2045311928 cites W2050122855 @default.
- W2045311928 cites W2050557145 @default.
- W2045311928 cites W2052644234 @default.
- W2045311928 cites W2058062440 @default.
- W2045311928 cites W2059470850 @default.
- W2045311928 cites W2060559699 @default.
- W2045311928 cites W2060729211 @default.
- W2045311928 cites W2061593125 @default.
- W2045311928 cites W2062649816 @default.
- W2045311928 cites W2063187675 @default.
- W2045311928 cites W2064040420 @default.
- W2045311928 cites W2064982295 @default.
- W2045311928 cites W2069508712 @default.
- W2045311928 cites W2071078959 @default.
- W2045311928 cites W2071874518 @default.
- W2045311928 cites W2072839306 @default.
- W2045311928 cites W2079558077 @default.
- W2045311928 cites W2080752012 @default.
- W2045311928 cites W2082184188 @default.
- W2045311928 cites W2090408997 @default.
- W2045311928 cites W2093498736 @default.
- W2045311928 cites W2097033861 @default.
- W2045311928 cites W2098559309 @default.
- W2045311928 cites W2100786079 @default.
- W2045311928 cites W2100796422 @default.
- W2045311928 cites W2107806009 @default.
- W2045311928 cites W2110139532 @default.
- W2045311928 cites W2114853101 @default.
- W2045311928 cites W2119445810 @default.
- W2045311928 cites W2123000765 @default.
- W2045311928 cites W2123343744 @default.
- W2045311928 cites W2126882378 @default.
- W2045311928 cites W2127624074 @default.
- W2045311928 cites W2129302018 @default.
- W2045311928 cites W2131091972 @default.
- W2045311928 cites W2131687641 @default.
- W2045311928 cites W2134146733 @default.
- W2045311928 cites W2142136448 @default.
- W2045311928 cites W2143241095 @default.
- W2045311928 cites W2144502512 @default.
- W2045311928 cites W2145837099 @default.
- W2045311928 cites W2152223912 @default.
- W2045311928 cites W2156545281 @default.
- W2045311928 cites W2159555403 @default.
- W2045311928 cites W2162222490 @default.
- W2045311928 cites W2163527113 @default.
- W2045311928 cites W2168260860 @default.
- W2045311928 doi "https://doi.org/10.1021/pr401224u" @default.
- W2045311928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24625128" @default.
- W2045311928 hasPublicationYear "2014" @default.
- W2045311928 type Work @default.
- W2045311928 sameAs 2045311928 @default.