FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045311990> ?p ?o ?g. }

• W2045311990 endingPage "380" @default.
• W2045311990 startingPage "367" @default.
• W2045311990 abstract "Pre-mRNA splicing factors are often redistributed to nucleoli in response to physiological conditions and cell stimuli. In telophase nuclei, serine-arginine rich (SR) proteins, which usually reside in nuclear speckles, localize transiently to active ribosomal DNA (rDNA) transcription sites called nucleolar organizing region-associated patches (NAPs). Here, we show that ultraviolet light and DNA damaging chemicals induce the redistribution of SR and SR-related proteins to areas around nucleolar fibrillar components in interphase nuclei that are similar to, but distinct from, NAPs, and these areas have been termed DNA damage-induced NAPs (d-NAPs). In vivo labeling of nascent RNA distinguished d-NAPs from NAPs in that d-NAPs were observed even after full rDNA transcriptional arrest as a result of DNA damage. Studies under a variety of conditions revealed that d-NAP formation requires both RNA polymerase II-dependent transcriptional arrest and nucleolar segregation, in particular, the disorganization of the granular nucleolar components. Despite the redistribution of SR proteins, splicing factor-enriched nuclear speckles were not disrupted because other nuclear speckle components, such as nuclear poly(A) RNA and the U5-116K protein, remained in DNA-damaged cells. These data suggest that the selective redistribution of splicing factors contributes to the regulation of specific genes via RNA metabolism. Finally, we demonstrate that a change in alternative splicing of apoptosis-related genes is coordinated with the occurrence of d-NAPs. Our results reveal a novel response to DNA damage that involves the dynamic redistribution of splicing factors to nucleoli." @default.
• W2045311990 created "2016-06-24" @default.
• W2045311990 creator A5001663062 @default.
• W2045311990 creator A5016357838 @default.
• W2045311990 date "2010-07-01" @default.
• W2045311990 modified "2023-10-14" @default.
• W2045311990 title "SR and SR-related proteins redistribute to segregated fibrillar components of nucleoli in a response to DNA damage" @default.
• W2045311990 cites W101837116 @default.
• W2045311990 cites W11162155 @default.
• W2045311990 cites W1642715359 @default.
• W2045311990 cites W1647720439 @default.
• W2045311990 cites W1879996757 @default.
• W2045311990 cites W1968578271 @default.
• W2045311990 cites W1970179052 @default.
• W2045311990 cites W1971250282 @default.
• W2045311990 cites W1974406569 @default.
• W2045311990 cites W1975283078 @default.
• W2045311990 cites W1979086700 @default.
• W2045311990 cites W1985490023 @default.
• W2045311990 cites W1986406001 @default.
• W2045311990 cites W1991985869 @default.
• W2045311990 cites W1997974981 @default.
• W2045311990 cites W1999440327 @default.
• W2045311990 cites W2001546866 @default.
• W2045311990 cites W2002373110 @default.
• W2045311990 cites W2003449953 @default.
• W2045311990 cites W2004024558 @default.
• W2045311990 cites W2005664674 @default.
• W2045311990 cites W2009183437 @default.
• W2045311990 cites W2010125195 @default.
• W2045311990 cites W2016493017 @default.
• W2045311990 cites W2021507904 @default.
• W2045311990 cites W2021739060 @default.
• W2045311990 cites W2021999304 @default.
• W2045311990 cites W2032527184 @default.
• W2045311990 cites W2036907121 @default.
• W2045311990 cites W2043972038 @default.
• W2045311990 cites W2045340640 @default.
• W2045311990 cites W2045547204 @default.
• W2045311990 cites W2045914521 @default.
• W2045311990 cites W2048544206 @default.
• W2045311990 cites W2057157392 @default.
• W2045311990 cites W2057842968 @default.
• W2045311990 cites W2068274700 @default.
• W2045311990 cites W2069297991 @default.
• W2045311990 cites W2077496230 @default.
• W2045311990 cites W2083309296 @default.
• W2045311990 cites W2085324214 @default.
• W2045311990 cites W2091955128 @default.
• W2045311990 cites W2092340900 @default.
• W2045311990 cites W2093549030 @default.
• W2045311990 cites W2094743769 @default.
• W2045311990 cites W2103250022 @default.
• W2045311990 cites W2103625519 @default.
• W2045311990 cites W2111023901 @default.
• W2045311990 cites W2111072547 @default.
• W2045311990 cites W2111204676 @default.
• W2045311990 cites W2114627554 @default.
• W2045311990 cites W2119176236 @default.
• W2045311990 cites W2119624960 @default.
• W2045311990 cites W2123847436 @default.
• W2045311990 cites W2131445177 @default.
• W2045311990 cites W2132300055 @default.
• W2045311990 cites W2133841696 @default.
• W2045311990 cites W2134762011 @default.
• W2045311990 cites W2138267133 @default.
• W2045311990 cites W2138346848 @default.
• W2045311990 cites W2138647063 @default.
• W2045311990 cites W2140011463 @default.
• W2045311990 cites W2141451721 @default.
• W2045311990 cites W2146609854 @default.
• W2045311990 cites W2150361747 @default.
• W2045311990 cites W2153404980 @default.
• W2045311990 cites W2153599010 @default.
• W2045311990 cites W2157780840 @default.
• W2045311990 cites W2158452003 @default.
• W2045311990 cites W2159864549 @default.
• W2045311990 cites W2160263647 @default.
• W2045311990 cites W2259023643 @default.
• W2045311990 cites W2617847000 @default.
• W2045311990 cites W36613289 @default.
• W2045311990 cites W4213068446 @default.
• W2045311990 cites W4255858411 @default.
• W2045311990 cites W48376435 @default.
• W2045311990 doi "https://doi.org/10.4161/nucl.1.4.12683" @default.
• W2045311990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3027045" @default.
• W2045311990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21327085" @default.
• W2045311990 hasPublicationYear "2010" @default.
• W2045311990 type Work @default.
• W2045311990 sameAs 2045311990 @default.
• W2045311990 citedByCount "26" @default.
• W2045311990 countsByYear W20453119902013 @default.
• W2045311990 countsByYear W20453119902014 @default.
• W2045311990 countsByYear W20453119902015 @default.
• W2045311990 countsByYear W20453119902016 @default.
• W2045311990 countsByYear W20453119902017 @default.
• W2045311990 countsByYear W20453119902018 @default.
• W2045311990 countsByYear W20453119902019 @default.

• next