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- W2045315121 abstract "The effect of doses of ascorbic acid ranging from 0 to 400 μg/ml of synthetic medium, has been investigated in cultures of 7-day chick limb-bone rudiments grown for eight days. The minimum concentration of ascorbic acid necessary to prevent the excessive hydration usually observed in bone rudiments in vitro was 50 μg/ml. A higher level of 80 μg/ml was the minimum dose that would support maximum collagen synthesis in the explants. Dehydroascorbic acid failed to prevent the hydration and did not promote collagen synthesis. Isoascorbic acid at 50 μg/ml was about one-third as active as an equal dose of ascorbic acid in promoting collagen synthesis." @default.
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- W2045315121 title "The synthesis of collagen by chick bone rudiments in vitro" @default.
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- W2045315121 doi "https://doi.org/10.1016/0014-4827(67)90208-x" @default.
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