FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045318076> ?p ?o ?g. }

• W2045318076 endingPage "156" @default.
• W2045318076 startingPage "141" @default.
• W2045318076 abstract "The POU domain transcription factor Brn-3b (also called Brn-3.2) is essential for the normal development of retinal ganglion cells (RGCs) in the mouse. Without Brn-3b, RGCs commit to their fate and migrate to the ganglion cell layer, but most cells die during fetal development. An earlier report (L. Gan et al., 1999, Dev. Biol. 210, 469-480) suggested that cell death was caused by abnormal axon formation. Here, we use retinal explants from wild-type and mutant embryos to show that brn-3b-deficient RGCs are not properly polarized and tend to form dendrites rather than axons. Compared with wild-type explants, neurites of RGCs from brn-3b-deficient retinal explants grew slower, were shorter, and did not fasciculate properly. Mutant neurites had more microtubules than wild-type controls, and the arrangement of microtubules and neurofilaments was characteristic of dendrites rather than axons. Neurites from individual mutant RGCs displayed abnormal polarity and had dendrite-like branches extending outward from their main axis. Most mutant RGCs exhibited abnormal migratory behavior, and their neurites labeled intensely with the dendrite marker MAP-2. A small number of mutant RGCs were not migratory, and their neurites were longer and labeled positively for the axon marker tau-1, suggesting that some RGCs were not as severely affected by the absence of Brn-3b as others. Although tau-1 was not observed in most mutant neurites, it did accumulate in mutant cell bodies, implying that the absence of Brn-3b caused a defect in axon transport. Thus, Brn-3b appears to control the activity of genes that function in establishing RGC polarity, and without Brn-3b, RGCs cannot extend normal axons." @default.
• W2045318076 created "2016-06-24" @default.
• W2045318076 creator A5008939990 @default.
• W2045318076 creator A5017928086 @default.
• W2045318076 creator A5019295921 @default.
• W2045318076 creator A5054351096 @default.
• W2045318076 date "2000-08-01" @default.
• W2045318076 modified "2023-10-01" @default.
• W2045318076 title "Abnormal Polarization and Axon Outgrowth in Retinal Ganglion Cells Lacking the POU-Domain Transcription Factor Brn-3b" @default.
• W2045318076 cites W1490295223 @default.
• W2045318076 cites W1868833618 @default.
• W2045318076 cites W1962175416 @default.
• W2045318076 cites W1971116733 @default.
• W2045318076 cites W1979386469 @default.
• W2045318076 cites W1985912987 @default.
• W2045318076 cites W1988939522 @default.
• W2045318076 cites W1991176878 @default.
• W2045318076 cites W1991623867 @default.
• W2045318076 cites W1994030229 @default.
• W2045318076 cites W2000700429 @default.
• W2045318076 cites W2001832813 @default.
• W2045318076 cites W2004154483 @default.
• W2045318076 cites W2008290466 @default.
• W2045318076 cites W2012153271 @default.
• W2045318076 cites W2019378194 @default.
• W2045318076 cites W2034214469 @default.
• W2045318076 cites W2039729151 @default.
• W2045318076 cites W2041808310 @default.
• W2045318076 cites W2044776028 @default.
• W2045318076 cites W2045858369 @default.
• W2045318076 cites W2055968613 @default.
• W2045318076 cites W2061122481 @default.
• W2045318076 cites W2063902684 @default.
• W2045318076 cites W2066556283 @default.
• W2045318076 cites W2070603983 @default.
• W2045318076 cites W2088940942 @default.
• W2045318076 cites W2121581131 @default.
• W2045318076 cites W2122268695 @default.
• W2045318076 cites W2124248841 @default.
• W2045318076 cites W2159913935 @default.
• W2045318076 cites W2167108743 @default.
• W2045318076 doi "https://doi.org/10.1006/mcne.2000.0860" @default.
• W2045318076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10924257" @default.
• W2045318076 hasPublicationYear "2000" @default.
• W2045318076 type Work @default.
• W2045318076 sameAs 2045318076 @default.
• W2045318076 citedByCount "77" @default.
• W2045318076 countsByYear W20453180762012 @default.
• W2045318076 countsByYear W20453180762013 @default.
• W2045318076 countsByYear W20453180762014 @default.
• W2045318076 countsByYear W20453180762015 @default.
• W2045318076 countsByYear W20453180762016 @default.
• W2045318076 countsByYear W20453180762017 @default.
• W2045318076 countsByYear W20453180762018 @default.
• W2045318076 countsByYear W20453180762019 @default.
• W2045318076 countsByYear W20453180762020 @default.
• W2045318076 countsByYear W20453180762021 @default.
• W2045318076 countsByYear W20453180762022 @default.
• W2045318076 countsByYear W20453180762023 @default.
• W2045318076 crossrefType "journal-article" @default.
• W2045318076 hasAuthorship W2045318076A5008939990 @default.
• W2045318076 hasAuthorship W2045318076A5017928086 @default.
• W2045318076 hasAuthorship W2045318076A5019295921 @default.
• W2045318076 hasAuthorship W2045318076A5054351096 @default.
• W2045318076 hasConcept C104317684 @default.
• W2045318076 hasConcept C105702510 @default.
• W2045318076 hasConcept C113246987 @default.
• W2045318076 hasConcept C121587040 @default.
• W2045318076 hasConcept C169760540 @default.
• W2045318076 hasConcept C196287685 @default.
• W2045318076 hasConcept C202751555 @default.
• W2045318076 hasConcept C2777093970 @default.
• W2045318076 hasConcept C2777624874 @default.
• W2045318076 hasConcept C2779530196 @default.
• W2045318076 hasConcept C54355233 @default.
• W2045318076 hasConcept C69125201 @default.
• W2045318076 hasConcept C86339819 @default.
• W2045318076 hasConcept C86803240 @default.
• W2045318076 hasConcept C95444343 @default.
• W2045318076 hasConceptScore W2045318076C104317684 @default.
• W2045318076 hasConceptScore W2045318076C105702510 @default.
• W2045318076 hasConceptScore W2045318076C113246987 @default.
• W2045318076 hasConceptScore W2045318076C121587040 @default.
• W2045318076 hasConceptScore W2045318076C169760540 @default.
• W2045318076 hasConceptScore W2045318076C196287685 @default.
• W2045318076 hasConceptScore W2045318076C202751555 @default.
• W2045318076 hasConceptScore W2045318076C2777093970 @default.
• W2045318076 hasConceptScore W2045318076C2777624874 @default.
• W2045318076 hasConceptScore W2045318076C2779530196 @default.
• W2045318076 hasConceptScore W2045318076C54355233 @default.
• W2045318076 hasConceptScore W2045318076C69125201 @default.
• W2045318076 hasConceptScore W2045318076C86339819 @default.
• W2045318076 hasConceptScore W2045318076C86803240 @default.
• W2045318076 hasConceptScore W2045318076C95444343 @default.
• W2045318076 hasIssue "2" @default.
• W2045318076 hasLocation W20453180761 @default.
• W2045318076 hasLocation W20453180762 @default.
• W2045318076 hasOpenAccess W2045318076 @default.

• next