FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045325780> ?p ?o ?g. }

• W2045325780 endingPage "392" @default.
• W2045325780 startingPage "386" @default.
• W2045325780 abstract "Hypertension is a major health problem and is usually associated with common conditions such as obesity, which contribute to clinical cardiac dysfunction. The role of energy homeostasis hormones such as ghrelin and PYY 3-36 in cardiovascular function remains incompletely understood. Therefore, the aim of our study was to explore the potential differences in concentrations of ghrelin forms and PYY 3-36 circulating in obese patients with grade 1 and grade 2 hypertension, with higher and lower BMI and without and with insulin resistance as well as to determine whether these hormones may be associated with left ventricular hypertrophy.A total of 142 adult subjects were studied in three subgroups: lean (BMI < 25 kg/m(2)) normotensive subjects and obese subjects (BMI 30.0-34.9 kg/m(2)), and obese subjects (BMI 35.0-39.9 kg/m(2)) under hypertensive treatment for at least 9 years. Fasting blood glucose, insulin, high-sensitivity C-reactive protein (hs-CRP), lipid profile, urinic acid, acylated ghrelin (A-Ghr), total ghrelin (T-Ghr), and PYY 3-36 were measured. Insulin resistance was determined by the homeostasis model assessment of insulin resistance (HOMA-IR). We also echocardiographically assessed left ventricular mass (LVM) index (LVMI = LVM/height(2.7)). We evaluated the association between plasma T-Ghr, A-Ghr, PYY 3-36 levels with LVMI and other measured factors using univariate and multivariate analysis.There were significant differences between BMI, waist circumference (WC), LVMI, hs-CRP and A-Ghr/nonacylated ghrelin (NA-Ghr) ratio (in the two obese subgroups. There was no significant difference between T-Ghr, A-Ghr and PYY 3-36 levels between obese subgroups. T-Ghr and PYY 3-36 were significantly lower in obese patients than in the control group, whereas A-Ghr levels did not differ between obese and controls. A-Ghr/NA-Ghr ratio was significantly higher in patients with second-degree hypertension and BMI 35.0-39.9 kg/m(2) than in patients with first-degree hypertension and BMI 30.0-34.9 kg/m(2). There were negative associations between T-Ghr, NA-Ghr or PYY 3-36 and LVMI (r = -0.49, p = 0.0001; r = -0.47, p = 0.0001; or r = -0.18, p = 0.029, respectively) and positive association between A-Ghr/NA-Ghr ratio and LVMI (r = 0.3, p = 0.0003). T-Ghr and NA-Ghr, were associated negatively with fasting insulin (r = -0.31, p = 0.0025; and r = -0.36, p = 0.001, repectively), while A-Ghr/NA-Ghr ratio was positively associated with BMI and fasting insulin (r = 0.23, p = 0.041; r = 0.3, p = 0.0045, respectively). T-Ghr, A-Ghr, and NAGhr were also inversely related to HOMA-IR indices in obese patients (r = -0.43, p = 0.001; r = -0.32, p = 0.0359; r = -0.35, p = 0.001, respectively). In insulin-resistant obese subjects T-Ghr and NA-Ghr correlated negatively with HOMA-IR (r = -0.34, p = 0.0015; r = -0.28, p = 0.0116, respectively). LVMI was associated negatively with T-Ghr, NA-Ghr and PYY 3-36 (r = -0.49, p = 0.0001; r = -0.47, p = 0.0001; r = -0.18, p = 0.029, respectively). In addition, LVMI was positively associated with A-Ghr/NA-Ghr ratio (r = 0.30, p = 0.0003).Plasma ghrelin forms and PYY 3-36 levels are associated with LVMI. These associations indicate a possible interaction between gut peptides and the cardiovascular system in hypertension and obesity." @default.
• W2045325780 created "2016-06-24" @default.
• W2045325780 creator A5004374062 @default.
• W2045325780 creator A5055168866 @default.
• W2045325780 creator A5063008536 @default.
• W2045325780 creator A5074369600 @default.
• W2045325780 creator A5078658859 @default.
• W2045325780 date "2011-01-01" @default.
• W2045325780 modified "2023-10-16" @default.
• W2045325780 title "Ghrelin PYY 3-36 Serum Changes in Left Ventricular Hypertrophic, Insulin-Resistant, Hypertensive Obese Patients" @default.
• W2045325780 cites W1868063534 @default.
• W2045325780 cites W1901716085 @default.
• W2045325780 cites W1967255785 @default.
• W2045325780 cites W1972512435 @default.
• W2045325780 cites W1977708624 @default.
• W2045325780 cites W1984097105 @default.
• W2045325780 cites W1989144464 @default.
• W2045325780 cites W1989237770 @default.
• W2045325780 cites W1995934832 @default.
• W2045325780 cites W2006243205 @default.
• W2045325780 cites W2006786285 @default.
• W2045325780 cites W2007168440 @default.
• W2045325780 cites W2028988838 @default.
• W2045325780 cites W2029114078 @default.
• W2045325780 cites W2049632194 @default.
• W2045325780 cites W2050121881 @default.
• W2045325780 cites W2051334171 @default.
• W2045325780 cites W2060716393 @default.
• W2045325780 cites W2067020618 @default.
• W2045325780 cites W2067688224 @default.
• W2045325780 cites W2076177143 @default.
• W2045325780 cites W2083874226 @default.
• W2045325780 cites W2088639163 @default.
• W2045325780 cites W2096459471 @default.
• W2045325780 cites W2097999273 @default.
• W2045325780 cites W2101998620 @default.
• W2045325780 cites W2102427927 @default.
• W2045325780 cites W2102790142 @default.
• W2045325780 cites W2105573142 @default.
• W2045325780 cites W2106636165 @default.
• W2045325780 cites W2119580431 @default.
• W2045325780 cites W2125751767 @default.
• W2045325780 cites W2131657910 @default.
• W2045325780 cites W2133576470 @default.
• W2045325780 cites W2143446008 @default.
• W2045325780 cites W2156386130 @default.
• W2045325780 cites W2163865122 @default.
• W2045325780 cites W2170567822 @default.
• W2045325780 cites W2303651371 @default.
• W2045325780 cites W2318020746 @default.
• W2045325780 cites W583814861 @default.
• W2045325780 doi "https://doi.org/10.1159/000334198" @default.
• W2045325780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6444480" @default.
• W2045325780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22166759" @default.
• W2045325780 hasPublicationYear "2011" @default.
• W2045325780 type Work @default.
• W2045325780 sameAs 2045325780 @default.
• W2045325780 citedByCount "7" @default.
• W2045325780 countsByYear W20453257802012 @default.
• W2045325780 countsByYear W20453257802014 @default.
• W2045325780 countsByYear W20453257802016 @default.
• W2045325780 countsByYear W20453257802019 @default.
• W2045325780 countsByYear W20453257802022 @default.
• W2045325780 crossrefType "journal-article" @default.
• W2045325780 hasAuthorship W2045325780A5004374062 @default.
• W2045325780 hasAuthorship W2045325780A5055168866 @default.
• W2045325780 hasAuthorship W2045325780A5063008536 @default.
• W2045325780 hasAuthorship W2045325780A5074369600 @default.
• W2045325780 hasAuthorship W2045325780A5078658859 @default.
• W2045325780 hasBestOaLocation W20453257801 @default.
• W2045325780 hasConcept C126322002 @default.
• W2045325780 hasConcept C134018914 @default.
• W2045325780 hasConcept C2776193436 @default.
• W2045325780 hasConcept C2777391703 @default.
• W2045325780 hasConcept C2778270857 @default.
• W2045325780 hasConcept C2779306644 @default.
• W2045325780 hasConcept C2779357093 @default.
• W2045325780 hasConcept C2780221984 @default.
• W2045325780 hasConcept C511355011 @default.
• W2045325780 hasConcept C555293320 @default.
• W2045325780 hasConcept C71315377 @default.
• W2045325780 hasConcept C71924100 @default.
• W2045325780 hasConceptScore W2045325780C126322002 @default.
• W2045325780 hasConceptScore W2045325780C134018914 @default.
• W2045325780 hasConceptScore W2045325780C2776193436 @default.
• W2045325780 hasConceptScore W2045325780C2777391703 @default.
• W2045325780 hasConceptScore W2045325780C2778270857 @default.
• W2045325780 hasConceptScore W2045325780C2779306644 @default.
• W2045325780 hasConceptScore W2045325780C2779357093 @default.
• W2045325780 hasConceptScore W2045325780C2780221984 @default.
• W2045325780 hasConceptScore W2045325780C511355011 @default.
• W2045325780 hasConceptScore W2045325780C555293320 @default.
• W2045325780 hasConceptScore W2045325780C71315377 @default.
• W2045325780 hasConceptScore W2045325780C71924100 @default.
• W2045325780 hasIssue "5" @default.
• W2045325780 hasLocation W20453257801 @default.
• W2045325780 hasLocation W20453257802 @default.
• W2045325780 hasLocation W20453257803 @default.

• next