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• W2045331852 abstract "1 The effects of humoral mediators of anaphylaxis on the bronchial function of the pithed rat have been assessed and compared with their effects in the guinea-pig and man. 2 5-Hydroxtryptamine, acetylcholine and bradykinin were bronchoconstrictor. Slow reacting substance in anaphylaxis and prostaglandin F2a caused only slight constriction at high doses and histamine was not active. 3 Bradykinin was less active in the rat than in the guinea-pig and its effects were not antagonized by anti-inflammatory analgesic drugs. 4 beta-Adrenoceptor blockade potentiated the activity of bradykinin but not that of 5-hydroxytryptamine or acetylcholine. 5 Dexamethasone reduced the activity of bradykinin but not that of 5-hydroxytryptamine or acetylcholine. 6 Sensitization with Nippostrogylus brasiliensis did not increase the sensitivity of the rat lung to the effects of mediators." @default.
• W2045331852 created "2016-06-24" @default.
• W2045331852 creator A5005978055 @default.
• W2045331852 date "1975-11-01" @default.
• W2045331852 modified "2023-10-09" @default.
• W2045331852 title "RESPONSE OF RAT LUNG TO HUMORAL MEDIATORS OF ANAPHYLAXIS AND ITS MODIFICATION BY DRUGS AND SENSITIZATION" @default.
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• W2045331852 doi "https://doi.org/10.1111/j.1476-5381.1975.tb06947.x" @default.
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