FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045332582> ?p ?o ?g. }

• W2045332582 endingPage "203" @default.
• W2045332582 startingPage "195" @default.
• W2045332582 abstract "In the Src Homology 3 domain (SH3) the RT and n-Src loops form a pocket that accounts for the specificity and affinity in binding of proline rich motifs (PRMs), while the distal and diverging turns play a key role in the folding of the protein. We have solved the structure of a chimeric mutant c-Src-SH3 domain where specific residues at the RT- and n-Src-loops have been replaced by those present in the corresponding Abl-SH3 domain. Crystals of the chimeric protein show a single molecule in the asymmetric unit, which appears in an unfolded-like structure that upon generation of the symmetry related molecules reveals the presence of a domain swapped dimer where both, RT- and n-Src loops, act as hinge loops. In contrast, the fold of the diverging type II β-turn and the distal loop are well conserved. Our results are the first evidence for the presence of a structured diverging type II β-turn in an unfolded-like intermediate of the c-Src-SH3 domain, which can be stabilized by interactions from the β-strands of the same polypeptide chain or from a neighboring one. Futhermore, this crystallographic structure opens a unique opportunity to study the effect of the amino acid sequence of the hinge loops on the 3D domain swapping process of c-Src-SH3." @default.
• W2045332582 created "2016-06-24" @default.
• W2045332582 creator A5024054858 @default.
• W2045332582 creator A5025331331 @default.
• W2045332582 creator A5029435044 @default.
• W2045332582 creator A5090028669 @default.
• W2045332582 date "2014-04-01" @default.
• W2045332582 modified "2023-10-18" @default.
• W2045332582 title "3D domain swapping in a chimeric c-Src SH3 domain takes place through two hinge loops" @default.
• W2045332582 cites W1510612347 @default.
• W2045332582 cites W1593625064 @default.
• W2045332582 cites W1593987163 @default.
• W2045332582 cites W1604656968 @default.
• W2045332582 cites W1860073488 @default.
• W2045332582 cites W1973163586 @default.
• W2045332582 cites W1984431560 @default.
• W2045332582 cites W1991498388 @default.
• W2045332582 cites W1991591212 @default.
• W2045332582 cites W1997937079 @default.
• W2045332582 cites W2001641653 @default.
• W2045332582 cites W2005986251 @default.
• W2045332582 cites W2006460346 @default.
• W2045332582 cites W2017614737 @default.
• W2045332582 cites W2019979803 @default.
• W2045332582 cites W2025822492 @default.
• W2045332582 cites W2026101733 @default.
• W2045332582 cites W2027166643 @default.
• W2045332582 cites W2030522763 @default.
• W2045332582 cites W2050791825 @default.
• W2045332582 cites W2052376307 @default.
• W2045332582 cites W2060257254 @default.
• W2045332582 cites W2065773261 @default.
• W2045332582 cites W2068528390 @default.
• W2045332582 cites W2071883240 @default.
• W2045332582 cites W2074655761 @default.
• W2045332582 cites W2076758778 @default.
• W2045332582 cites W2082019380 @default.
• W2045332582 cites W2110120447 @default.
• W2045332582 cites W2118958557 @default.
• W2045332582 cites W2122994276 @default.
• W2045332582 cites W2124026197 @default.
• W2045332582 cites W2132938122 @default.
• W2045332582 cites W2136567909 @default.
• W2045332582 cites W2137946890 @default.
• W2045332582 cites W2140721561 @default.
• W2045332582 cites W2144081223 @default.
• W2045332582 cites W2147874841 @default.
• W2045332582 cites W2149184367 @default.
• W2045332582 cites W2151687360 @default.
• W2045332582 cites W2154197653 @default.
• W2045332582 cites W2154714625 @default.
• W2045332582 cites W2163341755 @default.
• W2045332582 cites W2180229411 @default.
• W2045332582 cites W4210719442 @default.
• W2045332582 cites W4248872320 @default.
• W2045332582 doi "https://doi.org/10.1016/j.jsb.2014.02.007" @default.
• W2045332582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24556574" @default.
• W2045332582 hasPublicationYear "2014" @default.
• W2045332582 type Work @default.
• W2045332582 sameAs 2045332582 @default.
• W2045332582 citedByCount "6" @default.
• W2045332582 countsByYear W20453325822014 @default.
• W2045332582 countsByYear W20453325822015 @default.
• W2045332582 countsByYear W20453325822016 @default.
• W2045332582 countsByYear W20453325822019 @default.
• W2045332582 countsByYear W20453325822023 @default.
• W2045332582 crossrefType "journal-article" @default.
• W2045332582 hasAuthorship W2045332582A5024054858 @default.
• W2045332582 hasAuthorship W2045332582A5025331331 @default.
• W2045332582 hasAuthorship W2045332582A5029435044 @default.
• W2045332582 hasAuthorship W2045332582A5090028669 @default.
• W2045332582 hasConcept C104317684 @default.
• W2045332582 hasConcept C108636557 @default.
• W2045332582 hasConcept C113027372 @default.
• W2045332582 hasConcept C114614502 @default.
• W2045332582 hasConcept C119599485 @default.
• W2045332582 hasConcept C121332964 @default.
• W2045332582 hasConcept C123894998 @default.
• W2045332582 hasConcept C12554922 @default.
• W2045332582 hasConcept C127413603 @default.
• W2045332582 hasConcept C134306372 @default.
• W2045332582 hasConcept C147816474 @default.
• W2045332582 hasConcept C167625842 @default.
• W2045332582 hasConcept C170493617 @default.
• W2045332582 hasConcept C178790620 @default.
• W2045332582 hasConcept C181199279 @default.
• W2045332582 hasConcept C184720557 @default.
• W2045332582 hasConcept C185592680 @default.
• W2045332582 hasConcept C196347352 @default.
• W2045332582 hasConcept C2776545253 @default.
• W2045332582 hasConcept C2779546866 @default.
• W2045332582 hasConcept C33923547 @default.
• W2045332582 hasConcept C36503486 @default.
• W2045332582 hasConcept C40767141 @default.
• W2045332582 hasConcept C44000306 @default.
• W2045332582 hasConcept C55493867 @default.
• W2045332582 hasConcept C74650414 @default.
• W2045332582 hasConcept C8010536 @default.

• next