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- W2045335598 abstract "In this paper, we present a novel method to study the effect of induced mild hypothermia on cerebral vascular responses. To measure cerebral vascular responses, a minimally invasive imaging method, temporal laser speckle imaging, was developed and adapted for induced-hypothermia rat model. Experiments were carried out in rats under anesthesia. Laser speckle images were acquired at different temperature points, normothermia (37°C) and mild therapeutic hypothermia (34°C). We extracted multiple hemodynamic responses simultaneously from the images, including blood flow, vessel size and deoxy-hemoglobin saturation. A wide-field view of the cerebral vascular response distribution was studied, which showed an inhomogeneous response map across the region of interest. A comparison between responses in arterioles and venules was carried out (blood flow decreased by 58 ± 9 % vs. 27 ± 8 %). The global decrease of blood flow, dilatation in arterioles and decrease of deoxy-hemoglobin saturation in veins at mild hypothermia suggests a beneficial role of circulatory and oxygenation changes in therapeutic hypothermia. The results reported provide a circulatory explanation for the hypothermia therapeutic effects and mechanism." @default.
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- W2045335598 date "2011-08-01" @default.
- W2045335598 modified "2023-09-23" @default.
- W2045335598 title "Laser speckle imaging reveals multiple aspects of cerebral vascular responses to whole body mild hypothermia in rats" @default.
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- W2045335598 doi "https://doi.org/10.1109/iembs.2011.6090378" @default.
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