FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045342330> ?p ?o ?g. }

• W2045342330 endingPage "244" @default.
• W2045342330 startingPage "227" @default.
• W2045342330 abstract "Bis(tri-n-butyltin)oxide (TBTO) is one of the organotin compounds that have been used as biocides and occur as persistent environmental pollutants. Human exposure to these compounds occurs through consumption of meat and fish products in which they accumulate. The most sensitive endpoint of TBTO exposure is immunotoxicity. TBTO causes thymus atrophy and thereby interferes with T-lymphocyte-mediated immune responses. Tributyltin compounds have been found to adversely affect a wide range of cellular components and processes in many species, organ systems, and cell types. Both inhibition of proliferation and induction of apoptosis have been observed in thymocytes. We conducted microarray experiments in mice and rats in order to investigate if the immunosuppressive actions of TBTO could be detected by gene expression profiling, and if so, to elucidate the mechanisms of action. Gene expression changes that were detected in mouse thymuses after exposure to a maximum tolerable dose of TBTO correlated to previously observed effects. Most notably, reduction of expression of cell surface determinants and T-cell receptor chains, suppression of cell proliferation, and a possible involvement of nuclear receptors in interference with lipid metabolism by TBTO were observed. The TBTO-induced thymus involution may therefore primarily be caused by inhibition of thymocyte proliferation. In contrast, in rats only limited effects of a lower dose of TBTO were found at the gene expression level in the thymus, even though thymus involution was observed. Here, most gene expression regulation by TBTO was detected in the liver. These preliminary results indicate that gene expression analysis is able to reveal effects of TBTO and to gain insight into its molecular mechanism of action. It may even be a suitable tool to investigate immunotoxicology in general. However, dose and inter-species differences are apparently clearly reflected in the gene expression profiles." @default.
• W2045342330 created "2016-06-24" @default.
• W2045342330 creator A5005567085 @default.
• W2045342330 creator A5016943305 @default.
• W2045342330 creator A5034364029 @default.
• W2045342330 creator A5039109863 @default.
• W2045342330 creator A5071796957 @default.
• W2045342330 creator A5090080567 @default.
• W2045342330 date "2006-01-01" @default.
• W2045342330 modified "2023-10-15" @default.
• W2045342330 title "Gene Expression Profiling of Bis(tri-n-butyltin)oxide (TBTO)-Induced Immunotoxicity in Mice and Rats" @default.
• W2045342330 cites W1483133258 @default.
• W2045342330 cites W1578210758 @default.
• W2045342330 cites W1965644633 @default.
• W2045342330 cites W1969259773 @default.
• W2045342330 cites W1973569887 @default.
• W2045342330 cites W1973767228 @default.
• W2045342330 cites W1979164709 @default.
• W2045342330 cites W1979515338 @default.
• W2045342330 cites W1984315343 @default.
• W2045342330 cites W1987972127 @default.
• W2045342330 cites W1988951544 @default.
• W2045342330 cites W1991185023 @default.
• W2045342330 cites W1992229752 @default.
• W2045342330 cites W1994488865 @default.
• W2045342330 cites W1999269297 @default.
• W2045342330 cites W2001790945 @default.
• W2045342330 cites W2005320735 @default.
• W2045342330 cites W2005582404 @default.
• W2045342330 cites W2012385787 @default.
• W2045342330 cites W2012517281 @default.
• W2045342330 cites W2013612914 @default.
• W2045342330 cites W2015224451 @default.
• W2045342330 cites W2017056542 @default.
• W2045342330 cites W2025908558 @default.
• W2045342330 cites W2030007855 @default.
• W2045342330 cites W2033113520 @default.
• W2045342330 cites W2035375392 @default.
• W2045342330 cites W2036904911 @default.
• W2045342330 cites W2037235997 @default.
• W2045342330 cites W2040441208 @default.
• W2045342330 cites W2040540076 @default.
• W2045342330 cites W2042176133 @default.
• W2045342330 cites W2044911368 @default.
• W2045342330 cites W2046083481 @default.
• W2045342330 cites W2048844348 @default.
• W2045342330 cites W2050131628 @default.
• W2045342330 cites W2050698392 @default.
• W2045342330 cites W2051385700 @default.
• W2045342330 cites W2051840723 @default.
• W2045342330 cites W2052980405 @default.
• W2045342330 cites W2054954603 @default.
• W2045342330 cites W2055273792 @default.
• W2045342330 cites W2056915151 @default.
• W2045342330 cites W2057428268 @default.
• W2045342330 cites W2058544142 @default.
• W2045342330 cites W2060257756 @default.
• W2045342330 cites W2065060106 @default.
• W2045342330 cites W2066295067 @default.
• W2045342330 cites W2070052490 @default.
• W2045342330 cites W2077795832 @default.
• W2045342330 cites W2080000513 @default.
• W2045342330 cites W2080603531 @default.
• W2045342330 cites W2081045438 @default.
• W2045342330 cites W2081254567 @default.
• W2045342330 cites W2085471749 @default.
• W2045342330 cites W2086513741 @default.
• W2045342330 cites W2089700540 @default.
• W2045342330 cites W2091897891 @default.
• W2045342330 cites W2101123856 @default.
• W2045342330 cites W2111953454 @default.
• W2045342330 cites W2122056119 @default.
• W2045342330 cites W2126920933 @default.
• W2045342330 cites W2132483504 @default.
• W2045342330 cites W2132854878 @default.
• W2045342330 cites W2136138120 @default.
• W2045342330 cites W2136540393 @default.
• W2045342330 cites W2140689677 @default.
• W2045342330 cites W2141628779 @default.
• W2045342330 cites W2142613233 @default.
• W2045342330 cites W2144950148 @default.
• W2045342330 cites W2151574084 @default.
• W2045342330 cites W2154633696 @default.
• W2045342330 cites W2155663558 @default.
• W2045342330 cites W2157456005 @default.
• W2045342330 cites W2159568824 @default.
• W2045342330 cites W2164877856 @default.
• W2045342330 cites W2166534413 @default.
• W2045342330 cites W2167908723 @default.
• W2045342330 cites W2171062114 @default.
• W2045342330 cites W2397013215 @default.
• W2045342330 cites W2922341063 @default.
• W2045342330 cites W4254555723 @default.
• W2045342330 doi "https://doi.org/10.1080/15476910601023602" @default.
• W2045342330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18958704" @default.
• W2045342330 hasPublicationYear "2006" @default.
• W2045342330 type Work @default.
• W2045342330 sameAs 2045342330 @default.

• next