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- W2045343402 abstract "In 2000, investigators discovered Tribbles, a Drosophila protein that coordinates morphogenesis by inhibiting mitosis. Further work has delineated Xenopus (Xtrb2), Nematode (Nipi-3), and mammalian homologs of Drosophila tribbles, which include TRB1, TRB2, and TRB3. The sequences of tribbles homologs are highly conserved, and despite their protein kinase structure, to date they have not been shown to have kinase activity. TRB family members play a role in the differentiation of macrophages, lymphocytes, muscle cells, adipocytes, and osteoblasts. TRB isoforms also coordinate a number of critical cellular processes including glucose and lipid metabolism, inflammation, cellular stress, survival, apoptosis, and tumorigenesis. TRB family members modulate multiple complex signaling networks including mitogen activated protein kinase cascades, protein kinase B/AKT signaling, mammalian target of rapamycin, and inflammatory pathways. The following review will discuss metazoan homologs of Drosophila tribbles, their structure, expression patterns, and functions. In particular, we will focus on TRB3 function in the kidney in podocytes. This review will also discuss the key signaling pathways with which tribbles proteins interact and provide a rationale for developing novel therapeutics that exploit these interactions to provide better treatment options for both acute and chronic kidney disease." @default.
- W2045343402 created "2016-06-24" @default.
- W2045343402 creator A5059534457 @default.
- W2045343402 date "2013-01-01" @default.
- W2045343402 modified "2023-09-27" @default.
- W2045343402 title "Mammalian Tribbles Homologs at the Crossroads of Endoplasmic Reticulum Stress and Mammalian Target of Rapamycin Pathways" @default.
- W2045343402 cites W1481314844 @default.
- W2045343402 cites W1547014046 @default.
- W2045343402 cites W1581289874 @default.
- W2045343402 cites W1603786143 @default.
- W2045343402 cites W1711695767 @default.
- W2045343402 cites W1840278535 @default.
- W2045343402 cites W1897865160 @default.
- W2045343402 cites W1960908597 @default.
- W2045343402 cites W1964460778 @default.
- W2045343402 cites W1964526894 @default.
- W2045343402 cites W1964532554 @default.
- W2045343402 cites W1965784748 @default.
- W2045343402 cites W1966182052 @default.
- W2045343402 cites W1966683681 @default.
- W2045343402 cites W1966822894 @default.
- W2045343402 cites W1970384979 @default.
- W2045343402 cites W1971443890 @default.
- W2045343402 cites W1971799714 @default.
- W2045343402 cites W1972916221 @default.
- W2045343402 cites W1974351849 @default.
- W2045343402 cites W1976178491 @default.
- W2045343402 cites W1976531450 @default.
- W2045343402 cites W1978221635 @default.
- W2045343402 cites W1978293274 @default.
- W2045343402 cites W1980932234 @default.
- W2045343402 cites W1984485637 @default.
- W2045343402 cites W1985787110 @default.
- W2045343402 cites W1988588903 @default.
- W2045343402 cites W1990142715 @default.
- W2045343402 cites W1990400035 @default.
- W2045343402 cites W1991043567 @default.
- W2045343402 cites W1991331097 @default.
- W2045343402 cites W1991642946 @default.
- W2045343402 cites W1991997774 @default.
- W2045343402 cites W1993431505 @default.
- W2045343402 cites W1993908556 @default.
- W2045343402 cites W1996984419 @default.
- W2045343402 cites W1997532303 @default.
- W2045343402 cites W1998217509 @default.
- W2045343402 cites W1998399313 @default.
- W2045343402 cites W1998928623 @default.
- W2045343402 cites W2000179223 @default.
- W2045343402 cites W2001814858 @default.
- W2045343402 cites W2001871974 @default.
- W2045343402 cites W2003335967 @default.
- W2045343402 cites W2005307049 @default.
- W2045343402 cites W2006778876 @default.
- W2045343402 cites W2007857578 @default.
- W2045343402 cites W2008229793 @default.
- W2045343402 cites W2009617223 @default.
- W2045343402 cites W2009946316 @default.
- W2045343402 cites W2012258975 @default.
- W2045343402 cites W2012792172 @default.
- W2045343402 cites W2013465314 @default.
- W2045343402 cites W2013559520 @default.
- W2045343402 cites W2013966205 @default.
- W2045343402 cites W2017485253 @default.
- W2045343402 cites W2017913229 @default.
- W2045343402 cites W2018204057 @default.
- W2045343402 cites W2020063540 @default.
- W2045343402 cites W2020080621 @default.
- W2045343402 cites W2020133142 @default.
- W2045343402 cites W2020437934 @default.
- W2045343402 cites W2022400601 @default.
- W2045343402 cites W2022906603 @default.
- W2045343402 cites W2023395567 @default.
- W2045343402 cites W2023795446 @default.
- W2045343402 cites W2023839452 @default.
- W2045343402 cites W2024002811 @default.
- W2045343402 cites W2024749819 @default.
- W2045343402 cites W2026006752 @default.
- W2045343402 cites W2027065592 @default.
- W2045343402 cites W2029186790 @default.
- W2045343402 cites W2029653702 @default.
- W2045343402 cites W2030219313 @default.
- W2045343402 cites W2030714808 @default.
- W2045343402 cites W2031359784 @default.
- W2045343402 cites W2031706737 @default.
- W2045343402 cites W2033036465 @default.
- W2045343402 cites W2035863659 @default.
- W2045343402 cites W2037100826 @default.
- W2045343402 cites W2039031880 @default.
- W2045343402 cites W2039874922 @default.
- W2045343402 cites W2040098150 @default.
- W2045343402 cites W2040255749 @default.
- W2045343402 cites W2040333595 @default.
- W2045343402 cites W2041596037 @default.
- W2045343402 cites W2042646534 @default.
- W2045343402 cites W2044241702 @default.
- W2045343402 cites W2045158242 @default.
- W2045343402 cites W2045326722 @default.
- W2045343402 cites W2045531932 @default.