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• W2045344963 abstract "Abstract Ulcers in radiated skin continue to be a challenge for health care practitioners. Healing impairment in the setting of radiation‐damaged tissue will most of the time lead to chronic wounds that reduce the patient’s quality of life. In this review, we present an update of the pathophysiology of tissue damage caused by radiation that leads to chronic ulceration. We also explore the evidence available on the different prevention and treatment modalities that have been reported in the literature. The evidence for most preventive measures is inconclusive; however, sucralfate and amifostine seem to be the adequate recommendations for prophylaxis. As for treatment of ulcerated patients, the strongest level of evidence found was for the use of pentoxifylline, but proper trials are still scarce to be considered standard adjuvant therapy. Hyperbaric oxygen, cytokines and other growth factors and surgical interventions have shown some benefit in case reports and case series only. Other therapies show promise based on their mechanism of action but need to be tested in human studies and clinical trials." @default.
• W2045344963 created "2016-06-24" @default.
• W2045344963 creator A5000335647 @default.
• W2045344963 creator A5044102842 @default.
• W2045344963 creator A5046998187 @default.
• W2045344963 creator A5088650683 @default.
• W2045344963 date "2008-05-01" @default.
• W2045344963 modified "2023-10-18" @default.
• W2045344963 title "Wound healing in radiated skin: pathophysiology and treatment options" @default.
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• W2045344963 doi "https://doi.org/10.1111/j.1742-481x.2008.00436.x" @default.
• W2045344963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7951441" @default.
• W2045344963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18494630" @default.
• W2045344963 hasPublicationYear "2008" @default.
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