Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045345013> ?p ?o ?g. }
- W2045345013 endingPage "505" @default.
- W2045345013 startingPage "495" @default.
- W2045345013 abstract "Genitourinary (GU) tumors, and in particular renal cell and prostate cancer, represent one of the most dynamic areas in oncology from the scientific point of view. One of the most recent treatment approaches for GU tumors has focused on a series of molecules known as immune checkpoints and the possibility of manipulating immune responses against tumor cells by blocking these molecules with monoclonal antibodies (mAbs). Cytotoxic T lymphocyte antigen-4 (CTLA-4), and the immune checkpoint inhibitor mAbs ipilimumab and tremelimumab, represent the prototypes of this new growing class of agents called immunomodulating antibodies, while programmed death/ligand 1 (PD-1/PD-L1) also has garnered a significant interest as a new immune checkpoints to target in urothelial cancer, with the anti-PD-1/PD-L1 inhibitor mAbs nivolumab, MPDL-3280, and BMS-936559 as the first agents tested. Here we report the encouraging initial data observed in GU cancers with this new class of agents, which have reinforced the interest of investigating the therapeutic potential of the immune checkpoint modulators in large controlled trials." @default.
- W2045345013 created "2016-06-24" @default.
- W2045345013 creator A5008685924 @default.
- W2045345013 creator A5036574244 @default.
- W2045345013 creator A5061095811 @default.
- W2045345013 creator A5071881906 @default.
- W2045345013 creator A5084644964 @default.
- W2045345013 creator A5090942847 @default.
- W2045345013 creator A5091041625 @default.
- W2045345013 date "2015-06-01" @default.
- W2045345013 modified "2023-09-23" @default.
- W2045345013 title "Immunologic Checkpoints Blockade in Renal Cell, Prostate, and Urothelial Malignancies" @default.
- W2045345013 cites W1568317937 @default.
- W2045345013 cites W1606763503 @default.
- W2045345013 cites W1801789563 @default.
- W2045345013 cites W1829526068 @default.
- W2045345013 cites W1870078228 @default.
- W2045345013 cites W1904205116 @default.
- W2045345013 cites W1967884480 @default.
- W2045345013 cites W1972882573 @default.
- W2045345013 cites W1979811833 @default.
- W2045345013 cites W1985014438 @default.
- W2045345013 cites W1985219804 @default.
- W2045345013 cites W1985981664 @default.
- W2045345013 cites W1987446429 @default.
- W2045345013 cites W1992350807 @default.
- W2045345013 cites W1994812075 @default.
- W2045345013 cites W2010121426 @default.
- W2045345013 cites W2013616623 @default.
- W2045345013 cites W2013683525 @default.
- W2045345013 cites W2035660473 @default.
- W2045345013 cites W2041143310 @default.
- W2045345013 cites W2049163935 @default.
- W2045345013 cites W2057977955 @default.
- W2045345013 cites W2061419281 @default.
- W2045345013 cites W2063264144 @default.
- W2045345013 cites W2068081619 @default.
- W2045345013 cites W2069640477 @default.
- W2045345013 cites W2074651601 @default.
- W2045345013 cites W2080633739 @default.
- W2045345013 cites W2081447339 @default.
- W2045345013 cites W2082742146 @default.
- W2045345013 cites W2084538615 @default.
- W2045345013 cites W2100086637 @default.
- W2045345013 cites W2101653483 @default.
- W2045345013 cites W2102575291 @default.
- W2045345013 cites W2107752337 @default.
- W2045345013 cites W2117547860 @default.
- W2045345013 cites W2118471749 @default.
- W2045345013 cites W2118503880 @default.
- W2045345013 cites W2130066229 @default.
- W2045345013 cites W2130826590 @default.
- W2045345013 cites W2141427476 @default.
- W2045345013 cites W2141444851 @default.
- W2045345013 cites W2149121521 @default.
- W2045345013 cites W2149748445 @default.
- W2045345013 cites W2155995527 @default.
- W2045345013 cites W2160834915 @default.
- W2045345013 cites W2243346685 @default.
- W2045345013 cites W2298617717 @default.
- W2045345013 cites W2337805480 @default.
- W2045345013 cites W2395220548 @default.
- W2045345013 cites W2411664162 @default.
- W2045345013 cites W2463959934 @default.
- W2045345013 cites W2470779388 @default.
- W2045345013 cites W2499376400 @default.
- W2045345013 cites W2509124112 @default.
- W2045345013 cites W2528945028 @default.
- W2045345013 cites W2580751003 @default.
- W2045345013 cites W2591251181 @default.
- W2045345013 cites W289544031 @default.
- W2045345013 cites W3081413581 @default.
- W2045345013 cites W4205811845 @default.
- W2045345013 cites W4211144080 @default.
- W2045345013 cites W4230861071 @default.
- W2045345013 cites W4313635027 @default.
- W2045345013 doi "https://doi.org/10.1053/j.seminoncol.2015.02.004" @default.
- W2045345013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25965369" @default.
- W2045345013 hasPublicationYear "2015" @default.
- W2045345013 type Work @default.
- W2045345013 sameAs 2045345013 @default.
- W2045345013 citedByCount "40" @default.
- W2045345013 countsByYear W20453450132015 @default.
- W2045345013 countsByYear W20453450132016 @default.
- W2045345013 countsByYear W20453450132017 @default.
- W2045345013 countsByYear W20453450132018 @default.
- W2045345013 countsByYear W20453450132019 @default.
- W2045345013 countsByYear W20453450132020 @default.
- W2045345013 countsByYear W20453450132021 @default.
- W2045345013 countsByYear W20453450132022 @default.
- W2045345013 countsByYear W20453450132023 @default.
- W2045345013 crossrefType "journal-article" @default.
- W2045345013 hasAuthorship W2045345013A5008685924 @default.
- W2045345013 hasAuthorship W2045345013A5036574244 @default.
- W2045345013 hasAuthorship W2045345013A5061095811 @default.
- W2045345013 hasAuthorship W2045345013A5071881906 @default.
- W2045345013 hasAuthorship W2045345013A5084644964 @default.
- W2045345013 hasAuthorship W2045345013A5090942847 @default.