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• W2045346511 endingPage "1144" @default.
• W2045346511 startingPage "1135" @default.
• W2045346511 abstract "Oxidative stress inflicted by monocytes/macrophages (MO) is recognized as an important immunosuppressive mechanism in human neoplastic disease. We report that two types of lymphocytes of relevance for protection against malignant cells, T cells and natural killer (NK) cells, became anergic to the T cell and NK cell activator interleukin-2 (IL-2) after exposure to MO-derived reactive oxygen metabolites and subsequently acquired features characteristic of apoptosis. The MO-induced anergy and apoptosis in T cells and NK cells were reversed by histamine, an inhibitor of reactive oxygen metabolite synthesis in MO. We propose that strategies to circumvent oxidative inhibition of lymphocytes may be of benefit in immunotherapy of neoplastic disease." @default.
• W2045346511 created "2016-06-24" @default.
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• W2045346511 date "1999-10-01" @default.
• W2045346511 modified "2023-10-18" @default.
• W2045346511 title "Histamine Protects T Cells and Natural Killer Cells Against Oxidative Stress" @default.
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• W2045346511 doi "https://doi.org/10.1089/107999099313073" @default.
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