Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045350084> ?p ?o ?g. }
- W2045350084 endingPage "1047" @default.
- W2045350084 startingPage "1035" @default.
- W2045350084 abstract "Trifluoroacetylated (CF3CO-) proteins, elicited upon exposure of animals or humans to halothane, were recognized by anti-CF3CO antibody, monospecific for the hapten derivative N6-trifluoroacetyl-L-lysine. Anti-CF3CO antibodies cross-reacted with the dihydrolipoamide acetyltransferase (E2 subunit) of pyruvate dehydrogenase, indicating that epitopes on the E2 subunit of pyruvate dehydrogenase molecularly mimic those on CF3CO-proteins. Lipoic acid, the prosthetic group of the E2 subunit of pyruvate dehydrogenase was essential in this process, in that only the lipoylated form of the recombinantly expressed inner lipoyl domain of the human E2 subunit of pyruvate dehydrogenase, but not the unlipolyated form, was recognized by anti-CF3CO antibody. Furthermore, based on a high degree of structural relatedness, both CF3CO-Lys and (6RS)-lipoic acid, as well as the lipoylated peptide ETDK(lipoyl)ATIG specifically inhibited the recognition by anti-CF3CO antibody of the E2 subunit of pyruvate dehydrogenase, of trifluoroacetylated rabbit serum albumin and of human liver CF3CO-proteins. In sera of patients with halothane hepatitis, autoantibodies with properties identical to those of anti-CF3CO antibody were identified which could not discriminate between CF3CO-proteins and the E2 subunit of pyruvate dehydrogenase. These data suggest that the E2 subunit pyruvate of dehydrogenase is an autoantigen in halothane hepatitis and that molecular mimicry of CF3CO-proteins by the E2 subunit of pyruvate dehydrogenase is due to the similar structures of CF3CO-Lys and lipoic acid." @default.
- W2045350084 created "2016-06-24" @default.
- W2045350084 creator A5008669450 @default.
- W2045350084 creator A5021683292 @default.
- W2045350084 creator A5027019303 @default.
- W2045350084 creator A5028281331 @default.
- W2045350084 creator A5028679979 @default.
- W2045350084 creator A5040973492 @default.
- W2045350084 creator A5067712083 @default.
- W2045350084 date "1994-08-01" @default.
- W2045350084 modified "2023-10-02" @default.
- W2045350084 title "Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid" @default.
- W2045350084 cites W1586828670 @default.
- W2045350084 cites W1834991792 @default.
- W2045350084 cites W1975482007 @default.
- W2045350084 cites W1979823169 @default.
- W2045350084 cites W1984754777 @default.
- W2045350084 cites W1987002589 @default.
- W2045350084 cites W1987496501 @default.
- W2045350084 cites W1988888950 @default.
- W2045350084 cites W1996516844 @default.
- W2045350084 cites W1997489624 @default.
- W2045350084 cites W1998688744 @default.
- W2045350084 cites W2006572378 @default.
- W2045350084 cites W2006625001 @default.
- W2045350084 cites W2007362831 @default.
- W2045350084 cites W2011393733 @default.
- W2045350084 cites W2011735057 @default.
- W2045350084 cites W2013592796 @default.
- W2045350084 cites W2019522474 @default.
- W2045350084 cites W2021951643 @default.
- W2045350084 cites W2022976866 @default.
- W2045350084 cites W2026891958 @default.
- W2045350084 cites W2030083654 @default.
- W2045350084 cites W2036314272 @default.
- W2045350084 cites W2036348453 @default.
- W2045350084 cites W2037626742 @default.
- W2045350084 cites W2044316391 @default.
- W2045350084 cites W2046749316 @default.
- W2045350084 cites W2052232379 @default.
- W2045350084 cites W2053559460 @default.
- W2045350084 cites W2056074422 @default.
- W2045350084 cites W2068865134 @default.
- W2045350084 cites W2070857907 @default.
- W2045350084 cites W2078866938 @default.
- W2045350084 cites W2080938189 @default.
- W2045350084 cites W2081407843 @default.
- W2045350084 cites W2083851881 @default.
- W2045350084 cites W2086514665 @default.
- W2045350084 cites W2087358521 @default.
- W2045350084 cites W2088477504 @default.
- W2045350084 cites W2090290164 @default.
- W2045350084 cites W2091986547 @default.
- W2045350084 cites W2093304786 @default.
- W2045350084 cites W2094650210 @default.
- W2045350084 cites W2100837269 @default.
- W2045350084 cites W2101108802 @default.
- W2045350084 cites W2105619026 @default.
- W2045350084 cites W2118887037 @default.
- W2045350084 cites W2119967316 @default.
- W2045350084 cites W2122949244 @default.
- W2045350084 cites W2124295223 @default.
- W2045350084 cites W2143903248 @default.
- W2045350084 cites W2158660740 @default.
- W2045350084 cites W2168871876 @default.
- W2045350084 cites W2178350164 @default.
- W2045350084 cites W2342610199 @default.
- W2045350084 cites W4236091003 @default.
- W2045350084 doi "https://doi.org/10.1111/j.1432-1033.1994.tb19082.x" @default.
- W2045350084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7519986" @default.
- W2045350084 hasPublicationYear "1994" @default.
- W2045350084 type Work @default.
- W2045350084 sameAs 2045350084 @default.
- W2045350084 citedByCount "44" @default.
- W2045350084 countsByYear W20453500842012 @default.
- W2045350084 countsByYear W20453500842013 @default.
- W2045350084 countsByYear W20453500842016 @default.
- W2045350084 countsByYear W20453500842017 @default.
- W2045350084 countsByYear W20453500842018 @default.
- W2045350084 countsByYear W20453500842019 @default.
- W2045350084 countsByYear W20453500842020 @default.
- W2045350084 crossrefType "journal-article" @default.
- W2045350084 hasAuthorship W2045350084A5008669450 @default.
- W2045350084 hasAuthorship W2045350084A5021683292 @default.
- W2045350084 hasAuthorship W2045350084A5027019303 @default.
- W2045350084 hasAuthorship W2045350084A5028281331 @default.
- W2045350084 hasAuthorship W2045350084A5028679979 @default.
- W2045350084 hasAuthorship W2045350084A5040973492 @default.
- W2045350084 hasAuthorship W2045350084A5067712083 @default.
- W2045350084 hasBestOaLocation W20453500841 @default.
- W2045350084 hasConcept C104292427 @default.
- W2045350084 hasConcept C104317684 @default.
- W2045350084 hasConcept C120763696 @default.
- W2045350084 hasConcept C126093377 @default.
- W2045350084 hasConcept C151325109 @default.
- W2045350084 hasConcept C153911025 @default.
- W2045350084 hasConcept C179402230 @default.
- W2045350084 hasConcept C181199279 @default.