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- W2045355003 abstract "Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, especially the rate-limiting determinant of telomerase activity. So far, TERT has been reported to be over-expressed in more than 90% of cancers, thereby playing a critical role in sustained proliferation and survival potentials of various cancer cells. Over the past decade, a comprehensive network of transcription factors has been shown to be involved in the regulation of TERT. Furthermore, accumulating evidence has suggested that TERT could modulate the expression of numerous genes involved in diverse group of cellular processes, including cell cycle regulation and cellular signaling. Therefore, it indicates that TERT is both an effector and a regulator in carcinoma. However, the mechanisms of the interaction between TERT and its target genes are still not fully understood. Thus, it is necessary to consolidate and summarize recent developments of the cross-talk between TERT and related genes in cancer cells or other cells with cancer cell characteristics, and elucidate these relevant mechanisms. In this review, we focus on various signaling pathways and genes that participate in the feedback regulation of TERT and the underlying feedback loop mechanism of TERT, further providing new insights into non-telomeric functions of telomerase and potentially to be used as a novel therapeutic target for cancer." @default.
- W2045355003 created "2016-06-24" @default.
- W2045355003 creator A5007825172 @default.
- W2045355003 creator A5023108032 @default.
- W2045355003 creator A5027835055 @default.
- W2045355003 creator A5033281701 @default.
- W2045355003 creator A5038545320 @default.
- W2045355003 creator A5043155449 @default.
- W2045355003 creator A5050497078 @default.
- W2045355003 creator A5064830057 @default.
- W2045355003 date "2013-12-01" @default.
- W2045355003 modified "2023-10-16" @default.
- W2045355003 title "Feedback regulation of telomerase reverse transcriptase: new insight into the evolving field of telomerase in cancer" @default.
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