Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045358661> ?p ?o ?g. }
- W2045358661 endingPage "1019" @default.
- W2045358661 startingPage "1012" @default.
- W2045358661 abstract "The t(10;11)(p12;q14) is a recurring chromosomal translocation that gives rise to the CALM/AF10 fusion gene, which is found in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma. We analyzed the fusion transcripts in 20 new cases of CALM/AF10-positive leukemias, and compared the gene expression profile of 10 of these to 125 patients with other types of leukemia and 10 normal bone marrow samples. Based on gene set enrichment analyses, the CALM/AF10-positive samples showed significant upregulation of genes involved in chromatin assembly and maintenance and DNA repair process, and downregulation of angiogenesis and cell communication genes. Interestingly, we observed a striking upregulation of four genes located immediately centromeric to the break point of the t(10;11)(p12;q14) on 10p12 (COMMD3 (COMM domain containing 3), BMI1 (B lymphoma Mo-MLV insertion region 1 homolog), DNAJC1 (DnaJ (Hsp40) homolog subfamily C member 1) and SPAG6 (sperm associated antigen 6)). We also conducted semiquantitative reverse transcriptase-PCR analysis on leukemic blasts from a murine CALM/AF10 transplantation model that does not have the translocation. Commd3, Bmi1 and Dnajc1, but not Spag6 were upregulated in these samples. These results strongly indicate that the differential regulation of these three genes is not due to the break point effect but as a consequence of the CALM/AF10 fusion gene expression, though the mechanism of regulation is not well understood." @default.
- W2045358661 created "2016-06-24" @default.
- W2045358661 creator A5011513433 @default.
- W2045358661 creator A5014665369 @default.
- W2045358661 creator A5022277766 @default.
- W2045358661 creator A5030254190 @default.
- W2045358661 creator A5032050812 @default.
- W2045358661 creator A5032793816 @default.
- W2045358661 creator A5039233437 @default.
- W2045358661 creator A5047781859 @default.
- W2045358661 creator A5054494894 @default.
- W2045358661 creator A5058099757 @default.
- W2045358661 creator A5073421855 @default.
- W2045358661 creator A5080004893 @default.
- W2045358661 date "2011-11-08" @default.
- W2045358661 modified "2023-10-14" @default.
- W2045358661 title "CALM/AF10-positive leukemias show upregulation of genes involved in chromatin assembly and DNA repair processes and of genes adjacent to the breakpoint at 10p12" @default.
- W2045358661 cites W1567732942 @default.
- W2045358661 cites W1606221841 @default.
- W2045358661 cites W182858095 @default.
- W2045358661 cites W1965063715 @default.
- W2045358661 cites W1977895957 @default.
- W2045358661 cites W1992676863 @default.
- W2045358661 cites W1993240075 @default.
- W2045358661 cites W1995726096 @default.
- W2045358661 cites W1996419189 @default.
- W2045358661 cites W1996600754 @default.
- W2045358661 cites W2007525719 @default.
- W2045358661 cites W2014200955 @default.
- W2045358661 cites W2015416439 @default.
- W2045358661 cites W2016456457 @default.
- W2045358661 cites W2028885330 @default.
- W2045358661 cites W2031604577 @default.
- W2045358661 cites W2036605643 @default.
- W2045358661 cites W2038045605 @default.
- W2045358661 cites W2038259973 @default.
- W2045358661 cites W2039014113 @default.
- W2045358661 cites W2040192522 @default.
- W2045358661 cites W2048613921 @default.
- W2045358661 cites W2050314360 @default.
- W2045358661 cites W2052568445 @default.
- W2045358661 cites W2053468615 @default.
- W2045358661 cites W2059089115 @default.
- W2045358661 cites W2060473092 @default.
- W2045358661 cites W2060783518 @default.
- W2045358661 cites W2070582215 @default.
- W2045358661 cites W2093825780 @default.
- W2045358661 cites W2106134616 @default.
- W2045358661 cites W2113319573 @default.
- W2045358661 cites W2116043907 @default.
- W2045358661 cites W2124677401 @default.
- W2045358661 cites W2128438064 @default.
- W2045358661 cites W2130410032 @default.
- W2045358661 cites W2140555645 @default.
- W2045358661 cites W2141991853 @default.
- W2045358661 cites W2145307719 @default.
- W2045358661 cites W2147149482 @default.
- W2045358661 cites W2155911493 @default.
- W2045358661 cites W2156891393 @default.
- W2045358661 cites W2158773950 @default.
- W2045358661 cites W2163689497 @default.
- W2045358661 cites W2167469059 @default.
- W2045358661 cites W2171482205 @default.
- W2045358661 cites W2330513555 @default.
- W2045358661 cites W69594174 @default.
- W2045358661 cites W988244293 @default.
- W2045358661 doi "https://doi.org/10.1038/leu.2011.307" @default.
- W2045358661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22064352" @default.
- W2045358661 hasPublicationYear "2011" @default.
- W2045358661 type Work @default.
- W2045358661 sameAs 2045358661 @default.
- W2045358661 citedByCount "32" @default.
- W2045358661 countsByYear W20453586612012 @default.
- W2045358661 countsByYear W20453586612013 @default.
- W2045358661 countsByYear W20453586612014 @default.
- W2045358661 countsByYear W20453586612015 @default.
- W2045358661 countsByYear W20453586612016 @default.
- W2045358661 countsByYear W20453586612017 @default.
- W2045358661 countsByYear W20453586612018 @default.
- W2045358661 countsByYear W20453586612019 @default.
- W2045358661 countsByYear W20453586612020 @default.
- W2045358661 countsByYear W20453586612021 @default.
- W2045358661 countsByYear W20453586612022 @default.
- W2045358661 crossrefType "journal-article" @default.
- W2045358661 hasAuthorship W2045358661A5011513433 @default.
- W2045358661 hasAuthorship W2045358661A5014665369 @default.
- W2045358661 hasAuthorship W2045358661A5022277766 @default.
- W2045358661 hasAuthorship W2045358661A5030254190 @default.
- W2045358661 hasAuthorship W2045358661A5032050812 @default.
- W2045358661 hasAuthorship W2045358661A5032793816 @default.
- W2045358661 hasAuthorship W2045358661A5039233437 @default.
- W2045358661 hasAuthorship W2045358661A5047781859 @default.
- W2045358661 hasAuthorship W2045358661A5054494894 @default.
- W2045358661 hasAuthorship W2045358661A5058099757 @default.
- W2045358661 hasAuthorship W2045358661A5073421855 @default.
- W2045358661 hasAuthorship W2045358661A5080004893 @default.
- W2045358661 hasBestOaLocation W20453586611 @default.
- W2045358661 hasConcept C104317684 @default.