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• W2045360627 abstract "Infections due to meticillin-resistant Staphylococcus aureus (MRSA) pose a serious health risk. Novel methods for assessing comparative effectiveness and safety may provide valuable insights into therapeutic choices. We did a systematic review searching electronic databases including the archives of FDA/CDER and performed a Bayesian network meta-analysis to compare parenteral antibiotics used for treating hospitalised adults with complicated skin and soft-tissue infections (cSSTIs) or hospital-acquired or ventilator-associated pneumonia (HAP/VAP). Models were adjusted for clinical heterogeneity due to between-arm differences in the proportion of patients with diabetes (for cSSTI) and in those requiring mechanical ventilation (for pneumonia). Treatments were ranked on efficacy, defined as clinical success in the modified intention-to-treat population (MITT) and in the MITT population with MRSA at baseline (MRSA m-MITT), on all-cause mortality (in pneumonia only), and on serious adverse events and withdrawals due to adverse events. We identified 24 randomised controlled trials (17 for cSSTI and 10 for HAP/VAP) comparing one of six antibiotics with vancomycin. The network meta-analysis indicated that vancomycin ranked third (of six antibiotics) in cSSTI and second (of four) in pneumonia on both efficacy and safety. However, direct pairwise meta-analyses remained inconclusive as evidenced by the adjusted median odds ratios (ORs) and their 95% credible intervals. In cSSTI, linezolid and ceftaroline were non-significantly more effective than vancomycin. Linezolid ORs were 1.15 (0.74-1.71) and 1.01 (0.42-2.14) and ceftaroline ORs were 1.12 (0.78-1.64) and 1.59 (0.68-3.74) in the MITT and MRSA m-MITT populations, respectively. For HAP/VAP, linezolid was non-significantly better than vancomycin, with ORs of 1.05 (0.72-1.57) and 1.32 (0.71-2.48) in the MITT and MRSA m-MITT populations, respectively. We suspect performance and detection bias in cSSTI trials involving linezolid, but regression methods could not adjust for this potential bias. In these clinical trials, the preferred agents for treating serious MRSA infections were ceftaroline (for cSSTI, not studied in HAP/VAP) and linezolid. However, translation of these findings into practice should consider the small size of the evidence networks and the consequent uncertainty associated with the parameter estimates, the lack of evidence for ceftaroline in patients with severe renal impairment, and the lower internal validity of some of the linezolid trials." @default.
• W2045360627 created "2016-06-24" @default.
• W2045360627 creator A5008158125 @default.
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• W2045360627 date "2012-12-01" @default.
• W2045360627 modified "2023-10-02" @default.
• W2045360627 title "A network meta-analysis of antibiotics for treatment of hospitalised patients with suspected or proven meticillin-resistant Staphylococcus aureus infection" @default.
• W2045360627 cites W1536497620 @default.
• W2045360627 cites W1857740374 @default.
• W2045360627 cites W1867064160 @default.
• W2045360627 cites W1930006472 @default.
• W2045360627 cites W1965705252 @default.
• W2045360627 cites W1967385770 @default.
• W2045360627 cites W1969798675 @default.
• W2045360627 cites W1970548642 @default.
• W2045360627 cites W1976915176 @default.
• W2045360627 cites W1985184557 @default.
• W2045360627 cites W1987653198 @default.
• W2045360627 cites W1990570490 @default.
• W2045360627 cites W1996738507 @default.
• W2045360627 cites W2001604291 @default.
• W2045360627 cites W2002188750 @default.
• W2045360627 cites W2005265100 @default.
• W2045360627 cites W2010699829 @default.
• W2045360627 cites W2017882937 @default.
• W2045360627 cites W2019324782 @default.
• W2045360627 cites W2019351961 @default.
• W2045360627 cites W2038645302 @default.
• W2045360627 cites W2039997357 @default.
• W2045360627 cites W2040201598 @default.
• W2045360627 cites W2040587302 @default.
• W2045360627 cites W2046391772 @default.
• W2045360627 cites W2051834446 @default.
• W2045360627 cites W2052608732 @default.
• W2045360627 cites W2056271161 @default.
• W2045360627 cites W2057765075 @default.
• W2045360627 cites W2057910559 @default.
• W2045360627 cites W2059072492 @default.
• W2045360627 cites W2066729510 @default.
• W2045360627 cites W2072423352 @default.
• W2045360627 cites W2076533852 @default.
• W2045360627 cites W2078561636 @default.
• W2045360627 cites W2083674804 @default.
• W2045360627 cites W2090120393 @default.
• W2045360627 cites W2090874066 @default.
• W2045360627 cites W2095687971 @default.
• W2045360627 cites W2097083775 @default.
• W2045360627 cites W2099481682 @default.
• W2045360627 cites W2105669432 @default.
• W2045360627 cites W2105680863 @default.
• W2045360627 cites W2106765593 @default.
• W2045360627 cites W2108742677 @default.
• W2045360627 cites W2113144077 @default.
• W2045360627 cites W2115302674 @default.
• W2045360627 cites W2116607488 @default.
• W2045360627 cites W2118897654 @default.
• W2045360627 cites W2120732161 @default.
• W2045360627 cites W2123793178 @default.
• W2045360627 cites W2124161201 @default.
• W2045360627 cites W2125066910 @default.
• W2045360627 cites W2125096244 @default.
• W2045360627 cites W2126237265 @default.
• W2045360627 cites W2126915534 @default.
• W2045360627 cites W2126918925 @default.
• W2045360627 cites W2127383645 @default.
• W2045360627 cites W2128076923 @default.
• W2045360627 cites W2130403270 @default.
• W2045360627 cites W2134143967 @default.
• W2045360627 cites W2134287164 @default.
• W2045360627 cites W2134484797 @default.
• W2045360627 cites W2134833483 @default.
• W2045360627 cites W2134902065 @default.
• W2045360627 cites W2135788092 @default.
• W2045360627 cites W2136618123 @default.
• W2045360627 cites W2136645825 @default.
• W2045360627 cites W2137736234 @default.
• W2045360627 cites W2139088282 @default.
• W2045360627 cites W2140014835 @default.
• W2045360627 cites W2141604703 @default.
• W2045360627 cites W2146287754 @default.
• W2045360627 cites W2146844783 @default.
• W2045360627 cites W2147614544 @default.
• W2045360627 cites W2149993789 @default.
• W2045360627 cites W2149994900 @default.
• W2045360627 cites W2150388330 @default.
• W2045360627 cites W2151150074 @default.
• W2045360627 cites W2155301516 @default.
• W2045360627 cites W2155772830 @default.
• W2045360627 cites W2155965882 @default.
• W2045360627 cites W2157277150 @default.
• W2045360627 cites W2161582833 @default.
• W2045360627 cites W2163090854 @default.
• W2045360627 cites W2166414974 @default.
• W2045360627 cites W2166529480 @default.

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