FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045366950> ?p ?o ?g. }

• W2045366950 endingPage "2675" @default.
• W2045366950 startingPage "2657" @default.
• W2045366950 abstract "The CD200/CD200R inhibitory immune ligand–receptor system regulates microglial activation/quiescence in adult brain. Here, we investigated CD200/CD200R at different stages of postnatal development, when microglial maturation takes place. We characterized the spatiotemporal, cellular, and quantitative expression pattern of CD200 and CD200R in the developing and adult C57/BL6 mice brain by immunofluorescent labeling and Western blotting. CD200 expression increased from postnatal day 1 (P1) to P5–P7, when maximum levels were found, and decreased to adulthood. CD200 was located surrounding neuronal bodies, and very prominently in cortical layer I, where CD200+ structures included glial fibrillary acidic protein (GFAP)+ astrocytes until P7. In the hippocampus, CD200 was mainly observed in the hippocampal fissure, where GFAP+/CD200+ astrocytes were also found until P7. CD200+ endothelium was seen in the hippocampal fissure and cortical blood vessels, notably from P14, showing maximum vascular CD200 in adults. CD200R+ cells were a population of ameboid/pseudopodic Iba1+ microglia/macrophages observed at all ages, but significantly decreasing with increasing age. CD200R+/Iba1+ macrophages were prominent in the pial meninges and ventricle lining, mainly at P1–P5. CD200R+/Iba1+ perivascular macrophages were observed in cortical and hippocampal fissure blood vessels, showing maximum density at P7, but being prominent until adulthood. CD200R+/Iba1+ ameboid microglia in the cingulum at P1–P5 were the only CD200R+ cells in the nervous tissue. In conclusion, the main sites of CD200/CD200R interaction seem to include the molecular layer and pial surface in neonates and blood vessels from P7 until adulthood, highlighting the possible role of the CD200/CD200R system in microglial development and renewal. J. Comp. Neurol. 520:2657–2675, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2045366950 created "2016-06-24" @default.
• W2045366950 creator A5004424359 @default.
• W2045366950 creator A5020063047 @default.
• W2045366950 creator A5074309985 @default.
• W2045366950 date "2012-06-11" @default.
• W2045366950 modified "2023-10-17" @default.
• W2045366950 title "The immune inhibitory complex CD200/CD200R is developmentally regulated in the mouse brain" @default.
• W2045366950 cites W1120539415 @default.
• W2045366950 cites W1606537345 @default.
• W2045366950 cites W1608880972 @default.
• W2045366950 cites W1934664389 @default.
• W2045366950 cites W1966294767 @default.
• W2045366950 cites W1968178368 @default.
• W2045366950 cites W1972229100 @default.
• W2045366950 cites W1973715876 @default.
• W2045366950 cites W1974077164 @default.
• W2045366950 cites W1974626393 @default.
• W2045366950 cites W1975083734 @default.
• W2045366950 cites W1976814693 @default.
• W2045366950 cites W1979871839 @default.
• W2045366950 cites W1979890518 @default.
• W2045366950 cites W1983360436 @default.
• W2045366950 cites W1993748281 @default.
• W2045366950 cites W1998996300 @default.
• W2045366950 cites W1999494818 @default.
• W2045366950 cites W2000061964 @default.
• W2045366950 cites W2003674452 @default.
• W2045366950 cites W2008554619 @default.
• W2045366950 cites W2008750460 @default.
• W2045366950 cites W2010954821 @default.
• W2045366950 cites W2022438517 @default.
• W2045366950 cites W2029341006 @default.
• W2045366950 cites W2029429049 @default.
• W2045366950 cites W2029690491 @default.
• W2045366950 cites W2030342625 @default.
• W2045366950 cites W2033537883 @default.
• W2045366950 cites W2034387476 @default.
• W2045366950 cites W2035177674 @default.
• W2045366950 cites W2042230695 @default.
• W2045366950 cites W2045871368 @default.
• W2045366950 cites W2050593977 @default.
• W2045366950 cites W2051587095 @default.
• W2045366950 cites W2052812945 @default.
• W2045366950 cites W2053176712 @default.
• W2045366950 cites W2054178395 @default.
• W2045366950 cites W2055091163 @default.
• W2045366950 cites W2062559584 @default.
• W2045366950 cites W2066215889 @default.
• W2045366950 cites W2066331356 @default.
• W2045366950 cites W2067360858 @default.
• W2045366950 cites W2068501123 @default.
• W2045366950 cites W2068698671 @default.
• W2045366950 cites W2073895418 @default.
• W2045366950 cites W2074109330 @default.
• W2045366950 cites W2074287771 @default.
• W2045366950 cites W2077110494 @default.
• W2045366950 cites W2078755005 @default.
• W2045366950 cites W2079320514 @default.
• W2045366950 cites W2082139478 @default.
• W2045366950 cites W2083647875 @default.
• W2045366950 cites W2083998597 @default.
• W2045366950 cites W2084761937 @default.
• W2045366950 cites W2086641273 @default.
• W2045366950 cites W2088748012 @default.
• W2045366950 cites W2092709351 @default.
• W2045366950 cites W2093455511 @default.
• W2045366950 cites W2094012642 @default.
• W2045366950 cites W2114354962 @default.
• W2045366950 cites W2115049471 @default.
• W2045366950 cites W2115699016 @default.
• W2045366950 cites W2129141672 @default.
• W2045366950 cites W2136454105 @default.
• W2045366950 cites W2139720686 @default.
• W2045366950 cites W2144303480 @default.
• W2045366950 cites W2149859392 @default.
• W2045366950 cites W2149995749 @default.
• W2045366950 cites W2158496649 @default.
• W2045366950 cites W2158649743 @default.
• W2045366950 cites W2159744102 @default.
• W2045366950 cites W2159998015 @default.
• W2045366950 cites W2166711840 @default.
• W2045366950 cites W2167181852 @default.
• W2045366950 cites W2168548411 @default.
• W2045366950 cites W4229512970 @default.
• W2045366950 doi "https://doi.org/10.1002/cne.23062" @default.
• W2045366950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22323214" @default.
• W2045366950 hasPublicationYear "2012" @default.
• W2045366950 type Work @default.
• W2045366950 sameAs 2045366950 @default.
• W2045366950 citedByCount "47" @default.
• W2045366950 countsByYear W20453669502012 @default.
• W2045366950 countsByYear W20453669502013 @default.
• W2045366950 countsByYear W20453669502014 @default.
• W2045366950 countsByYear W20453669502015 @default.
• W2045366950 countsByYear W20453669502016 @default.
• W2045366950 countsByYear W20453669502017 @default.
• W2045366950 countsByYear W20453669502018 @default.

• next