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- W2045372138 abstract "Small rodents are the animals most utilized in investigating the effects of acute and long-term carbon monoxide intoxications. These animals can be used in sufficient numbers to produce statistically significant results. Furthermore, the 2- to 3-year life span of rats and mice enable life-long exposures and make possible studies of several subsequent generations in controlled environmental conditions. Experimental investigations of acute toxicity show differences related to age, sex, pregnancy, and adrenal factors. Differences in strains, body size, respiratory parameters, span of life, carboxyhemoglobin dissociation, endogen carbon monoxide production, and circadian rhythms must be taken into consideration when comparing results obtained with different animal models. Experiments of the effects of tobacco smoke and automotive exhaust are of great interest for they associate carbon monoxide with other toxic components that constitute a risk for human health." @default.
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- W2045372138 title "Animal models and acute and long-term carbon monoxide intoxication" @default.
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