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- W2045372639 endingPage "64" @default.
- W2045372639 startingPage "43" @default.
- W2045372639 abstract "Successful restoration of vision in human patients with gene therapy affirmed its promise to cure ocular diseases and disorders. The efficacy of gene therapy is contingent upon vector and mode of therapeutic DNA introduction into targeted cells/tissues. The cornea is an ideal tissue for gene therapy due to its ease of access and relative immune-privilege. Considerable progress has been made in the field of corneal gene therapy in last 5 years. Several new gene transfer vectors, techniques and approaches have evolved. Although corneal gene therapy is still in its early stages of development, the potential of gene-based interventions to treat corneal abnormalities has begun to surface. Identification of next generation viral and nanoparticle vectors, characterization of delivered gene levels, localization, and duration in the cornea, and significant success in controlling corneal disorders, particularly fibrosis and angiogenesis, in experimental animal disease models, with no major side effects have propelled gene therapy a step closer toward establishing gene-based therapies for corneal blindness. Recently, researchers have assessed the delivery of therapeutic genes for corneal diseases and disorders due to trauma, infections, chemical, mechanical, and surgical injury, and/or abnormal wound healing. This review provides an update on the developments in gene therapy for corneal diseases and discusses the barriers that hinder its utilization for delivering genes in the cornea." @default.
- W2045372639 created "2016-06-24" @default.
- W2045372639 creator A5012849717 @default.
- W2045372639 creator A5027806807 @default.
- W2045372639 creator A5038529776 @default.
- W2045372639 creator A5058413340 @default.
- W2045372639 date "2012-01-01" @default.
- W2045372639 modified "2023-09-25" @default.
- W2045372639 title "Gene therapy in the Cornea: 2005–present" @default.
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